(1S)-1-(3-Chlorophenyl)ethanamine

Basic Information

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CAS Number

68297-62-1

Molecular Formula

C8H10ClN

Molecular Weight

155.62 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Amines

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Boiling Point

112°C/13mm

Density

1.122

Flash Point

112°C/13mm

Refractive Index

1.551

SMILES

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CC(C1=CC(=CC=C1)Cl)N

InChI

InChI=1S/C8H10ClN/c1-6(10)7-3-2-4-8(9)5-7/h2-6H,10H2,1H3/t6-/m0/s1

InChIKey

DQEYVZASLGNODG-LURJTMIESA-N

LogP

2.3597

Topological Polar Surface Area

26.02 Å²

Hydrogen Bond Donor/Acceptor

2 / 1

Complexity

105

Safety Information

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Hazard Class

Class 8 Class 8

Sensitiveness

Moisture Sensitive

Synonyms & References

English

DTXSID70368841
A836089
(S)-3-Chloro-alpha-methylbenzylamine, ChiPros(R), produced by BASF, 99%
68297-62-1
(S)-1-(3-chlorophenyl)ethanamine
EN300-87767
CS-0000282
AS-75560
SCHEMBL2032469
AKOS010399809
(1S)-1-(3-chlorophenyl)ethan-1-amine
MFCD06761823
(S)-1-(3-Chlorophenyl)ethylamine
AC-2283
DQEYVZASLGNODG-LURJTMIESA-N
(1S)-1-(3-chlorophenyl)ethanamine
(S)-1-(3-Chlorophenyl)ethanamine
Benzenemethanamine, 3-chloro-a-methyl-,(S)-
Benzenemethanamine,3-chloro-a-methyl-, (S)-

MDL Number

MFCD06761823

Customs Code

2921499090

FAQ

What are the physical and chemical properties of (1S)-1-(3-Chlorophenyl)ethanamine (CAS: 68297-62-1)?

(1S)-1-(3-Chlorophenyl)ethanamine is a white crystalline solid with a molecular weight of approximately 185.61 g/mol. It has a slightly basic pH and is poorly soluble in water but more soluble in organic solvents like ethanol. Chemically, it is stable under normal conditions but reacts with strong acids and bases. It is used in organic synthesis and pharmaceuticals.

How is (1S)-1-(3-Chlorophenyl)ethanamine (CAS: 68297-62-1) typically synthesized?

(1S)-1-(3-Chlorophenyl)ethanamine can be synthesized through a Grignard reaction where phenylmagnesium bromide is added to 3-chloropropionaldehyde. The reaction is typically conducted in anhydrous ether, and the product is isolated by acid workup. This method provides good to excellent yield and can be optimized for batch or continuous flow processes.

What industries use (1S)-1-(3-Chlorophenyl)ethanamine (CAS: 68297-62-1)?

(1S)-1-(3-Chlorophenyl)ethanamine is primarily used in pharmaceuticals for the synthesis of certain drugs. It is also used in the production of certain polymers and as a precursor in organic synthesis. Additionally, it has applications in the development of sensors and semiconductors.

What precautions should be taken when handling (1S)-1-(3-Chlorophenyl)ethanamine (CAS: 68297-62-1)?

When handling (1S)-1-(3-Chlorophenyl)ethanamine, it is important to use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. The compound should be handled in a well-ventilated area or in a fume hood. Spills should be cleaned up immediately using appropriate absorbent materials. Always refer to the safety data sheet (SDS) for detailed handling and storage instructions.