(1S)-1-(2-Methoxyphenyl)ethanamine

Basic Information

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CAS Number

68285-24-5

Molecular Formula

C9H13NO

Molecular Weight

151.21 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Physical Properties

Physical State

Liquid

Boiling Point

118 °C/17 mmHg

Density

1.003

Water Solubility

Soluble in water(22 g/L).

Flash Point

118°C/17mm

Refractive Index

1.522

SMILES

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CC(C1=CC=CC=C1OC)N

InChI

InChI=1S/C9H13NO/c1-7(10)8-5-3-4-6-9(8)11-2/h3-7H,10H2,1-2H3/t7-/m0/s1

InChIKey

VENQOHAPVLVQKV-ZETCQYMHSA-N

LogP

1.7149

Topological Polar Surface Area

35.25 Å²

Hydrogen Bond Donor/Acceptor

2 / 2

Complexity

116

Safety Information

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Hazard Statement

H314 Causes severe skin burns and eye damage
Skin corrosion/irritation

H331 Toxic if inhaled
Acute toxicity, inhalation

Hazard Class

Class 8 Class 8

Sensitiveness

Air Sensitive

Synonyms & References

English

(S)-1-(2-Methoxyphenyl)ethylamine
AKOS015851754
68285-24-5
(S)-(-)-2-Methoxy a-methylbenzylamine
(1S)-1-(2-methoxyphenyl)ethylamine
MFCD00671658
(1S)-1-(2-methoxyphenyl)-ethylamine
VENQOHAPVLVQKV-ZETCQYMHSA-N
AKOS010377903
SCHEMBL334379
CS-0000284
(1S)-1-(2-methoxyphenyl)ethan-1-amine
(S)-1-(2-Methoxyphenyl)ethanamine
(s)-2-methoxy-alpha-methylbenzylamine
DTXSID30357392
(S)-2-Methoxy-alpha-methylbenzylamine, ChiPros(R), produced by BASF, 99%
(1S)-1-(2-methoxyphenyl)ethanamine
EN300-87753
(S)-1-(2-Methoxyphenyl)ethan-1-amine
AS-36150
Benzenemethanamine,2-methoxy-a-methyl-, (S)-
(-)-o-Methoxy-a-phenylethylamine
(-)-a-(o-Methoxyphenyl)ethylamine
(S)-o-Methoxy-a-phenethylamine
(1S)-1-(2-Methoxyphenyl)ethanamine

MDL Number

MFCD00671658

FAQ

What are the physical and chemical properties of (1S)-1-(2-Methoxyphenyl)ethanamine (CAS: 68285-24-5)?

(1S)-1-(2-Methoxyphenyl)ethanamine is a white crystalline solid with a molecular weight of approximately 168.24 g/mol. It is slightly soluble in water but more soluble in organic solvents. The compound is moderately reactive, particularly in basic conditions. It has a pKa of around 7.5, indicating it is a weak base.

How is (1S)-1-(2-Methoxyphenyl)ethanamine (CAS: 68285-24-5) typically synthesized?

(1S)-1-(2-Methoxyphenyl)ethanamine can be synthesized via aminomethylation of 2-methoxybenzene using water as the amine source. The reaction is typically conducted in the presence of a catalytic amount of a strong acid like sulfuric acid or hydrochloric acid. The yield is around 85-90%, with good selectivity to the (S)-enantiomer.

What industries use (1S)-1-(2-Methoxyphenyl)ethanamine (CAS: 68285-24-5)?

(1S)-1-(2-Methoxyphenyl)ethanamine is primarily used in the pharmaceutical industry as an intermediate for the synthesis of various drugs, particularly those targeting respiratory and cardiovascular systems. It is also used in the polymer industry for the preparation of certain functional polymers and in semiconductor applications for the development of sensor materials.

What precautions should be taken when handling (1S)-1-(2-Methoxyphenyl)ethanamine (CAS: 68285-24-5)?

When handling (1S)-1-(2-Methoxyphenyl)ethanamine, it is essential to wear appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. The compound should be stored in a cool, dry place away from direct sunlight. In case of spillage, it should be cleaned up with care, and appropriate emergency procedures should be followed. Always refer to the Safety Data Sheet (SDS) for detailed handling instructions and first aid measures.