5-Bromo-1,7-naphthyridin-8-amine

Basic Information

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CAS Number

67967-17-3

Molecular Formula

C8H6BrN3

Molecular Weight

224.06 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

SMILES

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C1=CC2=C(C(=NC=C2Br)N)N=C1

InChI

InChI=1S/C8H6BrN3/c9-6-4-12-8(10)7-5(6)2-1-3-11-7/h1-4H,(H2,10,12)

InChIKey

NGCIOHWBZLIGLV-UHFFFAOYSA-N

LogP

1.9745

Topological Polar Surface Area

51.8 Å²

Hydrogen Bond Donor/Acceptor

2 / 3

Complexity

164

Synonyms & References

English

MFCD09863859
5-Bromo-[1,7]naphthyridin-8-ylamine
67967-17-3
AKOS000271824
F1957-0054
SB38281
EN300-207087
5-bromo-1,7-naphthyridin-8-amine
SCHEMBL3380627
CS-0134057
FT-0710542
DTXSID20498384
AMY32594
8-Amino-5-bromo-1,7-naphthyridine
Z1269205087
AS-39929
5-Bromo-1,7-naphthyridin-8-amine
5-Bromo-8-amino-1,7-naphthyridin

MDL Number

MFCD09863859

Customs Code

2933990090

FAQ

What are the physical and chemical properties of 5-Bromo-1,7-naphthyridin-8-amine (CAS: 67967-17-3)?

5-Bromo-1,7-naphthyridin-8-amine is a crystalline solid with a molecular weight of approximately 244.04 g/mol. It has a low solubility in water but is soluble in organic solvents like ethanol and acetonitrile. Chemically, it is fairly stable but can undergo ring-opening reactions under basic conditions. It is a potential reagent in organic synthesis due to its bromine substituent.

How is 5-Bromo-1,7-naphthyridin-8-amine (CAS: 67967-17-3) typically synthesized?

5-Bromo-1,7-naphthyridin-8-amine is typically synthesized via bromination of 1,7-naphthyridin-8-amine using bromine in the presence of a base. The reaction requires stirring under an inert atmosphere to prevent oxidation. High selectivity and good yield are achieved with appropriate conditions, ensuring the bromine is attached to the desired position.

What industries use 5-Bromo-1,7-naphthyridin-8-amine (CAS: 67967-17-3)?

5-Bromo-1,7-naphthyridin-8-amine finds applications in the pharmaceutical industry, particularly in the development of potential antifungal agents. It is also used in polymer synthesis, where it can act as a functional monomer. Additionally, it has potential uses in sensor technology and semiconductor manufacturing due to its electronic properties.

What precautions should be taken when handling 5-Bromo-1,7-naphthyridin-8-amine (CAS: 67967-17-3)?

When handling 5-Bromo-1,7-naphthyridin-8-amine, ensure proper personal protective equipment (PPE) such as gloves and safety goggles. Work in a fume hood to minimize inhalation risks. Spills should be handled carefully, using appropriate neutralizing agents if necessary. Always consult the safety data sheet (SDS) for detailed handling and emergency procedures.