5-Bromo-1,7-naphthyridin-8-amine(CAS: 67967-17-3)

5-Bromo-1,7-naphthyridin-8-amine is a crystalline solid with a molecular weight of approximately 244.04 g/mol. It has a low solubility in water but is soluble in organic solvents like ethanol and acetonitrile. Chemically, it is fairly stable but can undergo ring-opening reactions under basic conditions. It is a potential reagent in organic synthesis due to its bromine substituent.

5-Bromo-1,7-naphthyridin-8-amine is typically synthesized via bromination of 1,7-naphthyridin-8-amine using bromine in the presence of a base. The reaction requires stirring under an inert atmosphere to prevent oxidation. High selectivity and good yield are achieved with appropriate conditions, ensuring the bromine is attached to the desired position.

5-Bromo-1,7-naphthyridin-8-amine finds applications in the pharmaceutical industry, particularly in the development of potential antifungal agents. It is also used in polymer synthesis, where it can act as a functional monomer. Additionally, it has potential uses in sensor technology and semiconductor manufacturing due to its electronic properties.

When handling 5-Bromo-1,7-naphthyridin-8-amine, ensure proper personal protective equipment (PPE) such as gloves and safety goggles. Work in a fume hood to minimize inhalation risks. Spills should be handled carefully, using appropriate neutralizing agents if necessary. Always consult the safety data sheet (SDS) for detailed handling and emergency procedures.