1-(5-Amino-2-fluorophenyl)ethanone

Basic Information

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CAS Number

67500-19-0

Molecular Formula

C8H8FNO

Molecular Weight

153.16 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ketones

Basic Chemical Raw Materials Organic Chemicals Amines

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Electronic Chemicals Semiconductor Materials Etchants

Basic Physical Properties

Melting Point

76-77 ºC (cyclohexane )

Density

1.201±0.06 g/cm3 (20 ºC 760 Torr),

SMILES

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CC(=O)C1=C(C=CC(=C1)N)F

InChI

InChI=1S/C8H8FNO/c1-5(11)7-4-6(10)2-3-8(7)9/h2-4H,10H2,1H3

InChIKey

WYTBQTMYNBKLHE-UHFFFAOYSA-N

LogP

1.6105

Topological Polar Surface Area

43.09 Å²

Hydrogen Bond Donor/Acceptor

2 / 2

Complexity

160

Synonyms & References

English

67500-19-0
EN300-198507
AKOS015995498
ETHANONE, 1-(5-AMINO-2-FLUOROPHENYL)-
SCHEMBL1440765
A867255
5-AMINO-2-FLUOROACETOPHENONE
1-(5-amino-2-fluoro-phenyl)ethanone
1-(5-amino-2-fluoro-phenyl)-ethanone
Ethanone, 1-(5-amino-2-fluorophenyl)- (9CI)
1-(5-Amino-2-fluorophenyl)ethan-1-one
SB76286
WYTBQTMYNBKLHE-UHFFFAOYSA-N
1-(5-amino-2-fluorophenyl)ethanone
MFCD02090052
FT-0698802
CS-W007111
5'-Amino-2'-fluoroacetophenone
J-503395
PS-8902
1-(5-Amino-2-fluorophenyl)ethanone
5-Amino-2-fluoroacetophenone
Ethanone, 1-(5-amino-2-fluorophenyl)-
3-Acetyl-4-fluoroaniline
5'-Amino-2'-fluoroecetophenone
2'-Fluoro-5'-aminoacetophenone
1-acetyl-5-amino-2-fluorobenzene
SBB086916
1-(5-amino-2-fluorophenyl)ethan-1-one

MDL Number

MFCD02090052

FAQ

What are the physical and chemical properties of 1-(5-Amino-2-fluorophenyl)ethanone (CAS: 67500-19-0)?

1-(5-Amino-2-fluorophenyl)ethanone (CAS: 67500-19-0) is a crystalline solid with a molecular weight of approximately 219.13 g/mol. It has a pKa of around 13.8 and is slightly soluble in water. Chemically, it is stable under normal conditions but may react with strong acids or bases due to its basic amino group.

How is 1-(5-Amino-2-fluorophenyl)ethanone (CAS: 67500-19-0) typically synthesized?

1-(5-Amino-2-fluorophenyl)ethanone can be synthesized via a multistep process from 2-fluorophenylacetic acid. A common method involves the nucleophilic aromatic substitution of the phenolic group followed by a reduction of the amide to an amine. This process yields high purity product with good yield and selectivity.

What industries use 1-(5-Amino-2-fluorophenyl)ethanone (CAS: 67500-19-0)?

1-(5-Amino-2-fluorophenyl)ethanone (CAS: 67500-19-0) is primarily used in the pharmaceutical industry for the synthesis of various drugs. It is also utilized in the polymer industry for the development of new materials and in the semiconductor industry for specific applications requiring its unique chemical properties.

What precautions should be taken when handling 1-(5-Amino-2-fluorophenyl)ethanone (CAS: 67500-19-0)?

When handling 1-(5-Amino-2-fluorophenyl)ethanone (CAS: 67500-19-0), it is essential to wear appropriate personal protective equipment (PPE), including gloves, safety goggles, and a lab coat. It should be handled in a well-ventilated area or a fume hood to prevent inhalation. Spills should be cleaned up with appropriate absorbents and disposed of according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed information and emergency procedures.