1-(5-Amino-2-fluorophenyl)ethanone(CAS: 67500-19-0)

1-(5-Amino-2-fluorophenyl)ethanone (CAS: 67500-19-0) is a crystalline solid with a molecular weight of approximately 219.13 g/mol. It has a pKa of around 13.8 and is slightly soluble in water. Chemically, it is stable under normal conditions but may react with strong acids or bases due to its basic amino group.

1-(5-Amino-2-fluorophenyl)ethanone can be synthesized via a multistep process from 2-fluorophenylacetic acid. A common method involves the nucleophilic aromatic substitution of the phenolic group followed by a reduction of the amide to an amine. This process yields high purity product with good yield and selectivity.

1-(5-Amino-2-fluorophenyl)ethanone (CAS: 67500-19-0) is primarily used in the pharmaceutical industry for the synthesis of various drugs. It is also utilized in the polymer industry for the development of new materials and in the semiconductor industry for specific applications requiring its unique chemical properties.

When handling 1-(5-Amino-2-fluorophenyl)ethanone (CAS: 67500-19-0), it is essential to wear appropriate personal protective equipment (PPE), including gloves, safety goggles, and a lab coat. It should be handled in a well-ventilated area or a fume hood to prevent inhalation. Spills should be cleaned up with appropriate absorbents and disposed of according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed information and emergency procedures.