4-chloro-5-iodo-pyridin-2-amine

Basic Information

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CAS Number

670253-37-9

Molecular Formula

C5H4ClIN2

Molecular Weight

254.46 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Boiling Point

326.8°C at 760 mmHg

Density

2.139±0.06 g/cm3 (20 ºC 760 Torr)

SMILES

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C1=C(C(=CN=C1N)I)Cl

InChI

InChI=1S/C5H4ClIN2/c6-3-1-5(8)9-2-4(3)7/h1-2H,(H2,8,9)

InChIKey

MBEBQNFNTISDFJ-UHFFFAOYSA-N

LogP

1.9218

Topological Polar Surface Area

38.91 Å²

Hydrogen Bond Donor/Acceptor

2 / 2

Complexity

101

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H332 Harmful if inhaled
Acute toxicity, inhalation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

CS-W022149
SY112535
DS-7007
MBEBQNFNTISDFJ-UHFFFAOYSA-N
MFCD11977433
4-Chloro-5-iodopyridin-2-amine
4-Chloro-5-iodopyridin-2-amine, AldrichCPR
697YNZ3PCA
4-chloro-5-iodo-2-pyridinamine
AC-33912
Z1269198371
2-Pyridinamine, 4-chloro-5-iodo-
4-Chloro-5-iodo-pyridin-2-ylamine
VBB25337
DTXSID30620614
AM807706
670253-37-9
2-AMINO-4-CHLORO-5-IODOPYRIDINE
SCHEMBL1485117
EN300-121953
AKOS016011769
F30223
A835612
2-Amino-4-chloro-5-iodopyridine
2-Pyridinamine, 4-chloro-5- iodo-
4-chloro-5-iodo-pyridin-2-ylamine
CTK5C5576
PubChem15065
QC-717
RW3323
SureCN1485117

MDL Number

MFCD11977433

FAQ

What are the physical and chemical properties of 4-chloro-5-iodo-pyridin-2-amine (CAS: 670253-37-9)?

4-Chloro-5-iodo-pyridin-2-amine (CAS: 670253-37-9) is a crystalline solid. Its molecular weight is approximately 297.02 g/mol. This compound has limited solubility in water but is more soluble in organic solvents like DMSO and DMA. It is mildly reactive towards nucleophiles. It is stable under normal conditions but should be stored in a cool, dry place to prevent hydrolysis.

How is 4-chloro-5-iodo-pyridin-2-amine (CAS: 670253-37-9) typically synthesized?

4-Chloro-5-iodo-pyridin-2-amine (CAS: 670253-37-9) can be synthesized by reacting 5-chloro-2-pyridamine with sodium iodide in the presence of a base such as potassium carbonate. This reaction is typically carried out in a suitable solvent like N,N-dimethylformamide (DMF) at room temperature. The yield can be improved by optimizing the reaction conditions and using high-purity reagents.

What industries use 4-chloro-5-iodo-pyridin-2-amine (CAS: 670253-37-9)?

4-Chloro-5-iodo-pyridin-2-amine (CAS: 670253-37-9) is primarily used in pharmaceuticals, specifically in drug synthesis for antimicrobial and antiviral compounds. It is also explored for its potential applications in sensor technology and as a precursor in the development of novel materials.

What precautions should be taken when handling 4-chloro-5-iodo-pyridin-2-amine (CAS: 670253-37-9)?

When handling 4-chloro-5-iodo-pyridin-2-amine (CAS: 670253-37-9), ensure proper personal protective equipment (PPE) is worn, including gloves, goggles, and a lab coat. Work in a well-ventilated area or a fume hood due to its potential for volatility. Spills should be managed carefully, using absorbent materials and disposing of them according to local regulations. Refer to the safety data sheet (SDS) for detailed handling and disposal information.