Betamethasone Dipropionate EP Impurity F (Betamethasone Dipropionate USP Related Compound F, Beclometasone Dipropionate EP Impurity J) | CAS No. 66917-44-0
Betamethasone Dipropionate EP Impurity F (Betamethasone Dipropionate USP Related Compound F, Beclometasone Dipropionate EP Impurity J)
Basic Information
CAS Number
66917-44-0
Molecular Formula
C28H36O7
Molecular Weight
484.59 g/mol
AD
Chemical Classification
Basic Physical Properties
Melting Point
143-145°C
Synonyms & References
English
- BECLOMETHASONE DIPROPIONATE IMPURITY J [EP IMPURITY]
- 9,11beta-Epoxy-16beta-methyl-3,20-dioxo-9beta-pregna-1,4-diene-17,21-diyl dipropanoate
- Betamethasone 9,11-Epoxide 17,21-Dipropionate
- 9beta,11beta-epoxy-16beta-methyl-pregna-1,4-diene-17,21-diol-3,20-dione 17,21-dipropionate
- 66917-44-0
- Betamethasone 9beta,11beta-epoxide 17,21-dipropionate
- Beclomethasone dipropionate impurity J
- Q27274457
- UNII-B79EV94J1X
- BETAMETHASONE 9.BETA.,11.BETA.-EPOXIDE 17,21-DIPROPIONATE
- Pregna-1,4-diene-3,20-dione, 9,11-epoxy-16-methyl-17,21-bis(1-oxopropoxy)-, (9beta,11beta,16beta)-
- DTXSID10628431
- [2-oxo-2-[(1S,2S,10S,11S,13S,14R,15S,17S)-2,13,15-trimethyl-5-oxo-14-propanoyloxy-18-oxapentacyclo[8.8.0.01,17.02,7.011,15]octadeca-3,6-dien-14-yl]ethyl] propanoate
- Betamethasone dipropionate impurity F
- 9.BETA.,11.BETA.-EPOXYBETAMETHASONE DIPROPIONATE
- BWSCDDHHJUGBSQ-XHYJHYNESA-N
- 9,11.BETA.-EPOXY-16.BETA.-METHYL-3,20-DIOXO-9.BETA.-PREGNA-1,4-DIENE-17,21-DIYL DIPROPANOATE
- (9beta,11beta,16beta)-16-Methyl-3,20-dioxo-9,11-epoxypregna-1,4-diene-17,21-diyl dipropanoate
- PREGNA-1,4-DIENE-3,20-DIONE, 9,11-EPOXY-16-METHYL-17,21-BIS(1-OXOPROPOXY)-, (9.BETA.,11.BETA.,16.BETA.)-
- SCHEMBL10908765
- B79EV94J1X
- 9beta,11beta-Epoxybetamethasone dipropionate
- BETAMETHASONE 9,11-EPOXIDE 17,21-DIPROPIONATE,WHITE SOLID
- A)-9,11-Epoxy-16-methyl-17,21-bis(1-oxopropoxy)pregna-1,4-diene-3,20-dione
- A,11
- A,16
- Beclomethasone 9,11-Epoxide 17,21-Dipropionate
- 2-oxo-2-((4aS,4bS,5aS,6aS,7R,8S,9aS,9bS)-4a,6a,8-trimethyl-2-oxo-7-(propionyloxy)-2,4a,5a,6,6a,7,8,9,9a,9b,10,11-dodecahydrocyclopenta[1,2]phenanthro[4,4a-b]oxiren-7-yl)ethyl propionate
FAQ
What are the physical and chemical properties of Betamethasone Dipropionate USP Related Compound F (CAS: 66917-44-0)?
Betamethasone Dipropionate USP Related Compound F is a white or practically white crystalline powder. Its molecular weight is approximately 508.6 g/mol, and it is sparingly soluble in water. It is less reactive compared to its parent compound, betamethasone dipropionate. It does not readily undergo hydrolysis under normal conditions, but its stability can be affected by pH and temperature.
How is Betamethasone Dipropionate USP Related Compound F (CAS: 66917-44-0) typically synthesized?
Betamethasone Dipropionate USP Related Compound F is typically synthesized by modifying the 16α-hydroxy group of betamethasone to form a propionate ester. The synthesis involves a four-step process: hydroxylation, acetylation, esterification, and ester cleavage. Commonly used catalysts include sodium hydride and sulfuric acid, with high selectivity and good yield.
What industries use Betamethasone Dipropionate USP Related Compound F (CAS: 66917-44-0)?
Betamethasone Dipropionate USP Related Compound F is primarily used in the pharmaceutical industry for the production of corticosteroid medications. It is also utilized in research for studying corticosteroid metabolism and pharmacological effects. Additionally, it can be used in the cosmetics industry as an anti-inflammatory agent.
What precautions should be taken when handling Betamethasone Dipropionate USP Related Compound F (CAS: 66917-44-0)?
When handling Betamethasone Dipropionate USP Related Compound F, it is essential to use personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood. Spills should be cleaned up immediately with appropriate absorbents and disposed of according to safety data sheet (SDS) guidelines. Always consult the latest SDS for specific handling and disposal instructions.
Related Compounds
![N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine structure](https://static.chemtradehub.com/structs/103/103687-96-3-8086.webp "N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine structure")
N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine
CAS Number:
103687-96-3
Molecular Formula:
C17H19NO5S
![5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine structure](https://static.chemtradehub.com/structs/112/112897-99-1-d1f4.webp "5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine structure")
5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine
CAS Number:
112897-99-1
Molecular Formula:
C30H31N3O7
![(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile structure](https://static.chemtradehub.com/structs/121/121055-10-5-583d.webp "(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile structure")
(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile
CAS Number:
121055-10-5
Molecular Formula:
C17H17NO4
![Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate structure](https://static.chemtradehub.com/structs/126/1263059-26-2-d6da.webp "Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate structure")
Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate
CAS Number:
1263059-26-2
Molecular Formula:
C8H6ClN3O2
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