Compound Q&A
How is Betamethasone Dipropionate USP Related Compound F (CAS: 66917-44-0) typically synthesized?
Answer
Betamethasone Dipropionate USP Related Compound F is typically synthesized by modifying the 16α-hydroxy group of betamethasone to form a propionate ester. The synthesis involves a four-step process: hydroxylation, acetylation, esterification, and ester cleavage. Commonly used catalysts include sodium hydride and sulfuric acid, with high selectivity and good yield.
About
CAS No
66917-44-0
English Name
Betamethasone Dipropionate EP Impurity F (Betamethasone Dipropionate USP Related Compound F, Beclometasone Dipropionate EP Impurity J)
Molecular Formula
C28H36O7
Molecular Weight
484.59 g/mol
SMILES
CCC(=O)OCC(=O)C1(C(CC2C1(CC3C4(C2CCC5=CC(=O)C=CC54C)O3)C)C)OC(=O)CC
InChIKey
BWSCDDHHJUGBSQ-XHYJHYNESA-N
Last Updated: 2026-03-05 02:11
