Goserelin | CAS No. 65807-02-5

Goserelin

Basic Information

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CAS Number

65807-02-5

Molecular Formula

C59H84N18O14

Molecular Weight

1269.43 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Boiling Point

1695.5 °Cat760mmHg

Density

1.5

Solubility

H2O: 20 mg/mL, clear, colorless

Refractive Index

1.692

SMILES

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CC(C)C[C@H](NC(=O)[C@@H](COC(C)(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc4c[nH]cn4)NC(=O)[C@@H]5CCC(=O)N5)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N6CCC[C@H]6C(=O)NNC(=O)N

InChI

InChI=1S/C59H84N18O14/c1-31(2)22-40(49(82)68-39(12-8-20-64-57(60)61)56(89)77-21-9-13-46(77)55(88)75-76-58(62)90)69-54(87)45(29-91-59(3,4)5)74-50(83)41(23-32-14-16-35(79)17-15-32)70-53(86)44(28-78)73-51(84)42(24-33-26-65-37-11-7-6-10-36(33)37)71-52(85)43(25-34-27-63-30-66-34)72-48(81)38-18-19-47(80)67-38/h6-7,10-11,14-17,26-27,30-31,38-46,65,78-79H,8-9,12-13,18-25,28-29H2,1-5H3,(H,63,66)(H,67,80)(H,68,82)(H,69,87)(H,70,86)(H,71,85)(H,72,81)(H,73,84)(H,74,83)(H,75,88)(H4,60,61,64)(H3,62,76,90)/t38-,39-,40-,41-,42-,43-,44-,45+,46-/m0/s1

InChIKey

BLCLNMBMMGCOAS-URPVMXJPSA-N

LogP

-2.8960300000000183

Topological Polar Surface Area

493.3899999999998 Å²

Hydrogen Bond Donor/Acceptor

20 / 32

Complexity

2560

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H312 Harmful in contact with skin
Acute toxicity, dermal

H317 May cause an allergic skin reaction
Sensitization, Skin

H332 Harmful if inhaled
Acute toxicity, inhalation

Synonyms & References

English

Goserelin
GOSERELIN ACETATE SALT
(D-SER(TBU)6,AZAGLY10)-GONADOTROPIN-RELEASING HORMONE ACETATE SALT
(D-SER(TBU)6,AZAGLY10)-LHRH ACETATE SALT
(D-SER(TBU)6,AZAGLY10)-LUTEINIZING HORMONE-RELEASING FACTOR ACETATE SALT
(D-SER(TBU)6,AZAGLY10)-LUTEINIZING HORMONE-RELEASING HORMONE ACETATE SALT
PYR-HIS-TRP-SER-TYR-D-SER(TBU)-LEU-ARG-PRO-AZAGLY-NH2 ACETATE SALT
2-(aminocarbonyl)hydrazide
decapeptidei
Goserelin Deuterated Acetate
(D-Ser(tBu)?00Azagly??)-LHRH(freebase)
(D-Ser(tBu)⁶,Azagly¹⁰)-LHRH (free base)
Pyr-His-Trp-Ser-D-Tyr-D-Ser(tBu)-Leu-Arg-Pro-Azagly-NH2
5-oxo-L-prolyl-L-histidyl-N-[(1S,4S,7R,10S,13S)-18,18-diamino-7-(tert-butoxymethyl)-13-({(2S)-2-[(2-carbamoylhydrazino)carbonyl]pyrrolidin-1-yl}carbonyl)-4-(4-hydroxybenzyl)-1-(hydrox
5-oxoprolylhistidyl-N-[18,18-diamino-7-(tert-butoxymethyl)-13-({2-[(2-carbamoylhydrazinyl)carbonyl]pyrrolidin-1-yl}carbonyl)-4-(4-hydroxybenzyl)-1-(hydroxymethyl)-10-(2-methylpropyl)-2,5,8,11-tetraoxo-3,6,9,12,17-pentaazaoctadec-17-en-1-yl]tryptophanamide
ICI118630
ICI-118630
Luteinizinghormone-releasing factor (pig),6-[O-(1,1-dimethylethyl)-D-serine]-10-deglycinamide-,2-(aminocarbonyl)hydrazide
Zoladex
(S)-N-((6S,9S,12R,15S,18S,21S,24S)-21-((1H-indol-3-yl)methyl)-1-amino-12-(tert-butoxymethyl)-6-((S)-2-(2-carbamoylhydrazine-1-carbonyl)pyrrolidine-1-carbonyl)-15-(4-hydroxybenzyl)-18-(hydroxymethyl)-25-(1H-imidazol-5-yl)-1-imino-9-isobutyl-8,11,14,17,20,23-hexaoxo-2,7,10,13,16,19,22-heptaazapentacosan-24-yl)-5-oxopyrrolidine-2-carboxamide

MDL Number

MFCD00867894

FAQ

What are the physical and chemical properties of Goserelin (CAS: 65807-02-5)?

Goserelin (CAS: 65807-02-5) is a white to off-white crystalline powder. Its molecular weight is approximately 688.55 g/mol. It is poorly soluble in water but soluble in organic solvents like ethanol and acetone. Chemically, it is a nonapeptide analogue of GnRH with high stability under most conditions, making it suitable for pharmaceutical applications.

How is Goserelin (CAS: 65807-02-5) typically synthesized?

Goserelin (CAS: 65807-02-5) is synthesized by the solid-phase peptide synthesis method. The process involves the stepwise addition of amino acids to a growing peptide chain, culminating in the final coupling of the nonapeptide. Commonly used coupling agents include HATU or PyBOP, and the overall yield is around 70-80%.

What industries use Goserelin (CAS: 65807-02-5)?

Goserelin (CAS: 65807-02-5) is primarily used in the pharmaceutical industry for hormonal therapy, particularly in the treatment of prostate cancer, endometriosis, and breast cancer. It is also used in the veterinary field for the control of reproductive function in animals.

What precautions should be taken when handling Goserelin (CAS: 65807-02-5)?

When handling Goserelin (CAS: 65807-02-5), appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat should be worn. Storage should be in a cool, dry place away from direct sunlight. In case of spill, use appropriate containment and clean up with an approved neutralizing agent before disposal. Always refer to the Safety Data Sheet (SDS) for specific handling guidelines.