Goserelin(CAS: 65807-02-5)

Goserelin (CAS: 65807-02-5) is a white to off-white crystalline powder. Its molecular weight is approximately 688.55 g/mol. It is poorly soluble in water but soluble in organic solvents like ethanol and acetone. Chemically, it is a nonapeptide analogue of GnRH with high stability under most conditions, making it suitable for pharmaceutical applications.

Goserelin (CAS: 65807-02-5) is synthesized by the solid-phase peptide synthesis method. The process involves the stepwise addition of amino acids to a growing peptide chain, culminating in the final coupling of the nonapeptide. Commonly used coupling agents include HATU or PyBOP, and the overall yield is around 70-80%.

Goserelin (CAS: 65807-02-5) is primarily used in the pharmaceutical industry for hormonal therapy, particularly in the treatment of prostate cancer, endometriosis, and breast cancer. It is also used in the veterinary field for the control of reproductive function in animals.

When handling Goserelin (CAS: 65807-02-5), appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat should be worn. Storage should be in a cool, dry place away from direct sunlight. In case of spill, use appropriate containment and clean up with an approved neutralizing agent before disposal. Always refer to the Safety Data Sheet (SDS) for specific handling guidelines.