Norgestrel | CAS No. 6533-00-2

Norgestrel

Basic Information

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CAS Number

6533-00-2

Molecular Formula

C21H28O2

Molecular Weight

312.4 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ketones

Basic Chemical Raw Materials Organic Chemicals Nitriles

Fine Chemicals Surfactants Anionic Surfactants

Polymers and Plastics Thermoplastics Polyolefins

Basic Physical Properties

Physical State

Powder

Melting Point

239-241 ºC

Boiling Point

392.36°C (rough estimate)

Density

1.0697 (rough estimate)

Refractive Index

1.4900 (estimate)

SMILES

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CCC12CCC3C(C1CCC2(C#C)O)CCC4=CC(=O)CCC34

InChI

InChI=1S/C21H28O2/c1-3-20-11-9-17-16-8-6-15(22)13-14(16)5-7-18(17)19(20)10-12-21(20,23)4-2/h2,13,16-19,23H,3,5-12H2,1H3/t16-,17+,18+,19-,20-,21-/m0/s1

InChIKey

WWYNJERNGUHSAO-XUDSTZEESA-N

LogP

3.8

Complexity

609

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

Q416950
Liletta
NORGESTREL [EP MONOGRAPH]
(+-)-13-Ethyl-17-hydroxy-18,19-dinor-17alpha-pregn-4-en-20-yn-3-one
C08149
D(-)-Norgestrel, analytical standard
Microlut
NORGESTREL COMPONENT OF OVRAL
NSC744007
LEVONORGESTREL [WHO-DD]
Skyla
17-Ethynyl-18-methyl-19-nortestosterone
AMY40476
OPILL
18,19-DINORPREGN-4-EN-20-YN-3-ONE, 13-ETHYL-17-HYDROXY-, (17.ALPHA.)-(+/-)-
Norgestrelum
13-Ethyl-17-alpha-ethynyl-17-beta-hydroxy-4-gonen-3-one
Triciclor
LEVONORGESTREL COMPONENT OF TWIRLA
Norplant II
NSC 759653
Triagynon
18,19-Dinor-13beta-ethyl-17beta-hydroxy-4-pregnen-20-yn-3-one
HMS2051M08
D00950
Skyla (TN)
LEVORA COMPONENT LEVONORGESTREL
Ld norgestrel
NORGESTREL [JAN]
LEVONEST COMPONENT LEVONORGESTREL
NORGESTREL [MI]

MDL Number

MFCD01546387

FAQ

What are the physical and chemical properties of Norgestrel (CAS: 6533-00-2)?

Norgestrel (CAS: 6533-00-2) is a white, crystalline, odorless substance. Its molecular weight is 338.42 g/mol. Norgestrel is practically insoluble in water but soluble in common organic solvents like ethanol and acetone. It is stable under normal storage conditions but reacts with strong acids to form norgesterol. Norgestrel is a progestin used in hormonal contraceptives and pregnancy tests.

How is Norgestrel (CAS: 6533-00-2) typically synthesized?

Norgestrel (CAS: 6533-00-2) is synthesized via a multi-step process involving acetylation of 17α-hydroxy-17β-ethynylestradiol, followed by reactions such as esterification and ring closure. Common catalysts include acetic anhydride, and the reaction yields are typically around 80-90%. The synthesis involves careful control of reaction conditions to achieve high selectivity.

What industries use Norgestrel (CAS: 6533-00-2)?

Norgestrel (CAS: 6533-00-2) is primarily used in the pharmaceutical industry, specifically in the production of hormonal contraceptives and pregnancy tests. It is also used in some formulations of combined oral contraceptives. Additionally, it can be found in certain topical applications for hormone replacement therapy.

What precautions should be taken when handling Norgestrel (CAS: 6533-00-2)?

When handling Norgestrel (CAS: 6533-00-2), it is important to wear appropriate personal protective equipment (PPE), including gloves and a lab coat. Work should be conducted in a well-ventilated area or fume hood. Spills should be cleaned up immediately with appropriate absorbent materials. Always consult the Safety Data Sheet (SDS) for specific handling and storage instructions. Norgestrel is stable under normal conditions but should avoid contact with strong acids to prevent decomposition.