Compound Q&A

How is Norgestrel (CAS: 6533-00-2) typically synthesized?

Answer

Norgestrel
Norgestrel (CAS: 6533-00-2) is synthesized via a multi-step process involving acetylation of 17α-hydroxy-17β-ethynylestradiol, followed by reactions such as esterification and ring closure. Common catalysts include acetic anhydride, and the reaction yields are typically around 80-90%. The synthesis involves careful control of reaction conditions to achieve high selectivity.

About

CAS No 6533-00-2
English Name Norgestrel
Molecular Formula C21H28O2
Molecular Weight 312.4 g/mol
SMILES CCC12CCC3C(C1CCC2(C#C)O)CCC4=CC(=O)CCC34
InChIKey WWYNJERNGUHSAO-XUDSTZEESA-N
Last Updated: 2025-10-13 15:08

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