(2R)-2-Amino-2-phenylacetamide

Basic Information

View in Editor

CAS Number

6485-67-2

Molecular Formula

C8H10N2O

Molecular Weight

150.18 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Amines

Fine Chemicals Dyes and Pigments Organic Dyes

Basic Physical Properties

Melting Point

125-129 ºC

Boiling Point

322.8°C at 760 mmHg

Density

1.1392 (rough estimate)

Flash Point

149℃

Refractive Index

1.6180 (estimate)

Specific Rotation

-48.5 º (c=0.55, EtOH)

SMILES

View in Editor

C1=CC=C(C=C1)C(C(=O)N)N

InChI

InChI=1S/C8H10N2O/c9-7(8(10)11)6-4-2-1-3-5-6/h1-5,7H,9H2,(H2,10,11)/t7-/m1/s1

InChIKey

KIYRSYYOVDHSPG-SSDOTTSWSA-N

LogP

0.17170000000000002

Topological Polar Surface Area

69.11 Å²

Hydrogen Bond Donor/Acceptor

4 / 3

Complexity

141

Safety Information

View Safety Information

Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H332 Harmful if inhaled
Acute toxicity, inhalation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

NS00021315
D-(-)-Phenylglycine amide
d(-)-phenylglycinamide, AldrichCPR
D(-)-PHENYLGLYCINAMIDE
2NDY0KO51E
d-phenylglycine amide
d-phenylglycinamide
BP-12536
SCHEMBL2332933
(2R)-2-amino-2-phenylethanamide
(R)-2-Amino-2-phenylacetamide
6485-67-2
A834906
UNII-2NDY0KO51E
KIYRSYYOVDHSPG-SSDOTTSWSA-N
MFCD06799064
Benzeneacetamide, a-amino-, (aR)-
Q27255108
[(1R)-2-amino-2-oxo-1-phenyl-ethyl]ammonium;(R)-2-Amino-2-phenylacetamide
(R)-(-)-2-Phenylglycine amide
O10163
GS-3126
CS-W019313
DTXSID30215140
(2r)-2-amino-2-phenylacetamide
EN300-118904
AKOS016842344
EC 420-370-0
D-(-)-Phenylglycine Amide
L-Phenylglycine amide
D-Phenylglycinamide

MDL Number

MFCD06799064

Customs Code

2924299090

FAQ

What are the physical and chemical properties of (2R)-2-Amino-2-phenylacetamide (CAS: 6485-67-2)?

(2R)-2-Amino-2-phenylacetamide (CAS: 6485-67-2) is a crystalline solid with a molecular weight of approximately 187.23 g/mol. It has a pKa of about 9.5 and is slightly soluble in water. This compound is relatively stable under normal conditions but can react with strong acids or bases. It is an important intermediate in the synthesis of various pharmaceuticals and agrochemicals.

How is (2R)-2-Amino-2-phenylacetamide (CAS: 6485-67-2) typically synthesized?

(2R)-2-Amino-2-phenylacetamide (CAS: 6485-67-2) is commonly synthesized via the amidation of 2-aminophenylacetic acid with phenylacetyl chloride in the presence of a base such as triethylamine. The reaction is typically carried out in a non-polar solvent like dichloromethane. This method offers high yield and good selectivity.

What industries use (2R)-2-Amino-2-phenylacetamide (CAS: 6485-67-2)?

(2R)-2-Amino-2-phenylacetamide (CAS: 6485-67-2) is widely used in the pharmaceutical and agrochemical industries as an intermediate. It also finds applications in the production of certain dyes and plastics. Its use in the polymer and semiconductor industries is less common but has potential for further development.

What precautions should be taken when handling (2R)-2-Amino-2-phenylacetamide (CAS: 6485-67-2)?

When handling (2R)-2-Amino-2-phenylacetamide (CAS: 6485-67-2), wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work in a well-ventilated area or fume hood to avoid inhalation of dust or vapors. Store the compound in a cool, dry place away from strong acids, bases, and oxidizers. Follow standard laboratory safety guidelines and consult the Safety Data Sheet (SDS) for detailed handling instructions.