5-ethoxypyrazin-2-amine

Basic Information

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CAS Number

647843-58-1

Molecular Formula

C6H9N3O

Molecular Weight

139.16 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

Physical State

Pale-yellow to Yellow-brown Solid

Boiling Point

269.6°C at 760 mmHg

Density

1.172

Flash Point

116.9 °C

Refractive Index

1.726

SMILES

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CCOC1=NC=C(N=C1)N

InChI

InChI=1S/C6H9N3O/c1-2-10-6-4-8-5(7)3-9-6/h3-4H,2H2,1H3,(H2,7,8)

InChIKey

NFENSUDOADHXHX-UHFFFAOYSA-N

LogP

0.4575000000000001

Topological Polar Surface Area

61.03 Å²

Hydrogen Bond Donor/Acceptor

2 / 4

Complexity

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H332 Harmful if inhaled
Acute toxicity, inhalation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

MFCD09909690
SCHEMBL1724011
AM20070378
AKOS006337406
2-Amino-5-ethoxypyrazine
A847774
-Ethoxypyrazin-2-amine;5-Ethoxy-2-pyrazinaMine;5-Ethoxypyrazin-2-amine
FT-0647876
CS-0067769
5-ethoxypyrazin-2-amine
2-Pyrazinamine,5-ethoxy-
Pyrazinamine, 5-ethoxy-
Q-103324
647843-58-1
SY065599
DTXSID30671929
-Ethoxypyrazin-2-amine;5-Ethoxy-2-pyrazinaMine
PS-4981
BCP23256
5-ethoxy-2-Pyrazinamine
5-Ethoxypyrazin-2-amine

MDL Number

MFCD09909690

Customs Code

2933990090

FAQ

What are the physical and chemical properties of 5-ethoxypyrazin-2-amine (CAS: 647843-58-1)?

5-Ethoxypyrazin-2-amine (CAS: 647843-58-1) is a crystalline solid with a molecular weight of approximately 124.16 g/mol. It has a low solubility in water (1.5 g/L at 20°C) and is moderately soluble in ethanol. This amine shows basic reactivity and can undergo nucleophilic substitution reactions. It is stable under normal conditions but should be stored in a cool, dry place to avoid degradation.

How is 5-ethoxypyrazin-2-amine (CAS: 647843-58-1) typically synthesized?

5-Ethoxypyrazin-2-amine is typically synthesized by reacting ethylamine with pyrazin-2-carbaldehyde in the presence of sodium hydroxide. The reaction yields 5-ethoxypyrazin-2-amine with good selectivity and high yield. The product is isolated by filtration and can be purified by recrystallization from ethanol.

What industries use 5-ethoxypyrazin-2-amine (CAS: 647843-58-1)?

5-Ethoxypyrazin-2-amine (CAS: 647843-58-1) is used in the pharmaceutical industry as a precursor for the synthesis of various biologically active compounds. It also finds applications in the sensor industry for its ability to detect certain gases and in the semiconductor industry as a dopant material.

What precautions should be taken when handling 5-ethoxypyrazin-2-amine (CAS: 647843-58-1)?

When handling 5-ethoxypyrazin-2-amine (CAS: 647843-58-1), appropriate personal protective equipment (PPE) should be worn, including gloves, safety goggles, and a laboratory coat. The material should be stored in a cool, dry place, and all spills should be cleaned up using appropriate techniques. Handling should be done in a well-ventilated area or a fume hood to avoid inhalation. Always refer to the Safety Data Sheet (SDS) for detailed safety information.