1-[3-(Dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carboxamide | CAS No. 64372-56-1
1-[3-(Dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carboxamide
Basic Information
CAS Number
64372-56-1
Molecular Formula
C20H23FN2O2
Molecular Weight
342.41 g/mol
AD
Chemical Classification
Basic Physical Properties
Melting Point
126-128 ºC (ethanol )
Density
1.183±0.06 g/cm3 (20 ºC 760 Torr),
Synonyms & References
English
- Citalopram Related Compound A
- 1-[3-(Dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofurancarboxamide
- 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-3H-2-benzofuran-5-carboxamide
- 5-carboxamide citalopram
- UNII-BP83XJ2B6A
MDL Number
MFCD24857372
FAQ
What are the physical and chemical properties of 1-[3-(Dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carboxamide (CAS: 64372-56-1)?
This compound has a crystalline form with a molecular weight of approximately 351.27 g/mol. It is slightly soluble in water but more soluble in organic solvents like ethanol and DMSO. Chemically, it is stable under normal conditions but can undergo hydrolysis under acidic or basic conditions. It is also known to be reactive towards nucleophiles and electrophiles.
How is 1-[3-(Dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carboxamide (CAS: 64372-56-1) typically synthesized?
This compound is typically synthesized using a multi-step process involving a condensation reaction between a diethyl malonate derivative and a 4-fluoroaniline. The reaction is catalyzed by a Lewis acid like aluminum trichloride, and the yield is around 70-80%. Further purification is achieved through recrystallization and chromatography.
What industries use 1-[3-(Dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carboxamide (CAS: 64372-56-1)?
This compound is primarily used in the pharmaceutical industry for its potential as a drug precursor. It is also explored in the polymer industry for its potential as a monomer or additive. Additionally, it has applications in the sensor and semiconductor industries due to its electronic properties.
What precautions should be taken when handling 1-[3-(Dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carboxamide (CAS: 64372-56-1)?
Proper handling requires the use of personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted under a fume hood to minimize exposure. Spills should be cleaned up using appropriate absorbents, and the area should be well-ventilated. Always refer to the safety data sheet (SDS) for detailed emergency procedures and storage requirements.
Related Compounds
![N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine structure](https://static.chemtradehub.com/structs/103/103687-96-3-8086.webp "N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine structure")
N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine
CAS Number:
103687-96-3
Molecular Formula:
C17H19NO5S
![5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine structure](https://static.chemtradehub.com/structs/112/112897-99-1-d1f4.webp "5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine structure")
5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine
CAS Number:
112897-99-1
Molecular Formula:
C30H31N3O7
![(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile structure](https://static.chemtradehub.com/structs/121/121055-10-5-583d.webp "(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile structure")
(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile
CAS Number:
121055-10-5
Molecular Formula:
C17H17NO4
![Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate structure](https://static.chemtradehub.com/structs/126/1263059-26-2-d6da.webp "Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate structure")
Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate
CAS Number:
1263059-26-2
Molecular Formula:
C8H6ClN3O2
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