Compound Q&A
How is 1-[3-(Dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carboxamide (CAS: 64372-56-1) typically synthesized?
Answer
![1-[3-(Dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carboxamide](https://static.chemtradehub.com/structs/643/64372-56-1-476d.webp "1-[3-(Dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carboxamide")
This compound is typically synthesized using a multi-step process involving a condensation reaction between a diethyl malonate derivative and a 4-fluoroaniline. The reaction is catalyzed by a Lewis acid like aluminum trichloride, and the yield is around 70-80%. Further purification is achieved through recrystallization and chromatography.
About
CAS No
64372-56-1
English Name
1-[3-(Dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carboxamide
Molecular Formula
C20H23FN2O2
Molecular Weight
342.41 g/mol
SMILES
O=C(C1=CC2=C(C(C3=CC=C(F)C=C3)(CCCN(C)C)OC2)C=C1)N
InChIKey
LYYWQJNKWCANAC-UHFFFAOYSA-N
Last Updated: 2026-03-01 17:12
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