Pramoxine Hydrochloride

Basic Information

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CAS Number

637-58-1

Molecular Formula

C17H28ClNO3

Molecular Weight

329.87 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Melting Point

181-183°C

Boiling Point

427°C at 760 mmHg

Flash Point

123.5 °C

SMILES

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CCCCOC1=CC=C(OCCCN2CCOCC2)C=C1.[H]Cl

InChI

InChI=1S/C17H27NO3.ClH/c1-2-3-12-20-16-5-7-17(8-6-16)21-13-4-9-18-10-14-19-15-11-18;/h5-8H,2-4,9-15H2,1H3;1H

InChIKey

SYCBXBCPLUFJID-UHFFFAOYSA-N

LogP

3.388400000000003

Topological Polar Surface Area

30.930000000000003 Å²

Hydrogen Bond Donor/Acceptor

0 / 4

Complexity

248

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Toxicity

LD50 i.v. in mice: 79.5 ±2.7 mg/kg (Schmidt); LD50 in mice (mg/kg): 300 i.p., 750 s.c. (Monash, Gibbs)

Synonyms & References

English

PRAMOXINE HYDROCHLORIDE
4-(3-(p-butoxyphenoxy)propyl)-morpholinhydrochloride
gamma-morpholinopropyl4-n-butoxyphenyletherhydrochloride
p-butoxyphenylgamma-morpholinopropyletherhydrochloride
proctofoam
PRAMOXINE HCL
PRAXOMINE HYDROCHLORIDE
TRONOTHANE HYDROCHLORIDE
4-[3-(P-BUTOXYPHENOXY)PROPYL]MORPHOLINE HYDROCHLORIDE
4-N-BUTOXYPHENYL G-MORPHOLINOPROPYL ETHER HYDROCHLORIDE
pramocaine hydrochloride
PRAMOXINE HCL USP
TRONOTHANE HYDROCHLORIDE USP
4-[3-(4-butoxyphenoxy)propyl]morpholine,hydrochloride
PRAMOXINE HYDROCHLORIDE,USP
4-n-Butoxyphenyl gamma-morpholinopropyl ether hydrochloride
4-[3-(4-Butoxyphenoxy)propyl]morpholine hydrochloride
Pramoxine hydrochloride
Pramocaine hydrochloride

MDL Number

MFCD00054323

Customs Code

2934999090

FAQ

What are the physical and chemical properties of Pramoxine Hydrochloride (CAS: 637-58-1)?

Pramoxine hydrochloride is a white or off-white crystalline powder with a molecular weight of approximately 268.83 g/mol. It is sparingly soluble in water and ethanol. Chemically, it is highly reactive under basic conditions and stable under acidic conditions. The compound is not flammable and has a low tendency to undergo hydrolysis or oxidation at room temperature.

How is Pramoxine Hydrochloride (CAS: 637-58-1) typically synthesized?

Pramoxine hydrochloride is synthesized from pramoxine, a secondary amine, by reacting it with hydrochloric acid. Common methods involve the use of concentrated hydrochloric acid in an aqueous solution, where the amine protonates to form the hydrochloride salt. The reaction is typically carried out at room temperature, yielding a product with a high degree of purity and selectivity.

What industries use Pramoxine Hydrochloride (CAS: 637-58-1)?

Pramoxine hydrochloride is widely used in the pharmaceutical industry, particularly in the formulation of topical anesthetics for pain relief. It is also used in some cosmetic products to reduce discomfort during procedures. Additionally, it has applications in the medical field for its local anesthetic properties.

What precautions should be taken when handling Pramoxine Hydrochloride (CAS: 637-58-1)?

When handling pramoxine hydrochloride, it is important to wear gloves, protective goggles, and a lab coat to prevent skin and eye contact. The compound should be stored in a cool, dry place away from direct sunlight and heat sources. In case of a spill, it should be cleaned up immediately using appropriate disposal methods, and the area should be well-ventilated. Always refer to the Safety Data Sheet (SDS) for detailed handling and storage instructions.