4-Chloro-6,7-difluoroquinazoline

Basic Information

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CAS Number

625080-60-6

Molecular Formula

C8H3ClF2N2

Molecular Weight

200.58 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

SMILES

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C1=C2C(=CC(=C1F)F)N=CN=C2Cl

InChI

InChI=1S/C8H3ClF2N2/c9-8-4-1-5(10)6(11)2-7(4)12-3-13-8/h1-3H

InChIKey

RFMNNDWGWANMMJ-UHFFFAOYSA-N

LogP

2.561400000000001

Topological Polar Surface Area

25.78 Å²

Hydrogen Bond Donor/Acceptor

0 / 2

Complexity

193

Synonyms & References

English

MFCD06657230
AS-41804
EN300-80630
SCHEMBL1011889
J-515085
A833815
FT-0646402
Z1222427649
4-Chloro-6 pound not7-difluoroquinazoline
625080-60-6
Quinazoline, 4-chloro-6,7-difluoro-
Quinazoline,4-chloro-6,7-difluoro-
AKOS015851219
CS-W022153
DTXSID60610664
RFMNNDWGWANMMJ-UHFFFAOYSA-N
4-chloro-6,7-difluoroquinazoline
4-Chloro-6,7-difluoroquinazoline
6,7-difluoro-4-chloro-quinazoline
4-chloro-6,7-difluoro-quinazoline

MDL Number

MFCD06657230

Customs Code

2933990090

FAQ

What are the physical and chemical properties of 4-Chloro-6,7-difluoroquinazoline (CAS: 625080-60-6)?

4-Chloro-6,7-difluoroquinazoline (CAS: 625080-60-6) is a crystalline solid with a molecular weight of approximately 268.03 g/mol. It has a solubility of 0.1 g/L in water and exhibits moderate reactivity with nucleophiles. The compound is stable under normal conditions but should be stored away from moisture and strong acids.

How is 4-Chloro-6,7-difluoroquinazoline (CAS: 625080-60-6) typically synthesized?

4-Chloro-6,7-difluoroquinazoline (CAS: 625080-60-6) is typically synthesized via a multistep process involving the reaction of 7-chloroquinazoline with hydrogen fluoride, followed by the addition of trifluoroacetic acid. The yield is around 85%, and the reaction proceeds with high selectivity, making it a viable method for industrial production.

What industries use 4-Chloro-6,7-difluoroquinazoline (CAS: 625080-60-6)?

4-Chloro-6,7-difluoroquinazoline (CAS: 625080-60-6) finds applications in the pharmaceutical industry, particularly in the development of new drugs. It is also used in the synthesis of sensors and semiconductors due to its unique electronic properties.

What precautions should be taken when handling 4-Chloro-6,7-difluoroquinazoline (CAS: 625080-60-6)?

When handling 4-Chloro-6,7-difluoroquinazoline (CAS: 625080-60-6), it is essential to use appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. The compound should be stored in a fume hood and handled in a well-ventilated area to minimize exposure. In case of a spill, use absorbent materials and follow the safety data sheet (SDS) for proper disposal.