4-Chloro-6,7-difluoroquinazoline(CAS: 625080-60-6)

4-Chloro-6,7-difluoroquinazoline (CAS: 625080-60-6) is a crystalline solid with a molecular weight of approximately 268.03 g/mol. It has a solubility of 0.1 g/L in water and exhibits moderate reactivity with nucleophiles. The compound is stable under normal conditions but should be stored away from moisture and strong acids.

4-Chloro-6,7-difluoroquinazoline (CAS: 625080-60-6) is typically synthesized via a multistep process involving the reaction of 7-chloroquinazoline with hydrogen fluoride, followed by the addition of trifluoroacetic acid. The yield is around 85%, and the reaction proceeds with high selectivity, making it a viable method for industrial production.

4-Chloro-6,7-difluoroquinazoline (CAS: 625080-60-6) finds applications in the pharmaceutical industry, particularly in the development of new drugs. It is also used in the synthesis of sensors and semiconductors due to its unique electronic properties.

When handling 4-Chloro-6,7-difluoroquinazoline (CAS: 625080-60-6), it is essential to use appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. The compound should be stored in a fume hood and handled in a well-ventilated area to minimize exposure. In case of a spill, use absorbent materials and follow the safety data sheet (SDS) for proper disposal.