2,5-Bis(hydroxymethyl)-1,4-dioxane-2,5-diol

Basic Information

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CAS Number

62147-49-3

Molecular Formula

C6H12O6

Molecular Weight

180.16 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

Melting Point

75-80 ºC

Boiling Point

232.96°C (rough estimate)

Density

1.2805 (rough estimate)

Water Solubility

Soluble in ethanol, ethyl ether, acetone. Slightly soluble in water. Insoluble in ligroin.

Refractive Index

1.5730 (estimate)

SMILES

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O[C@@]1(CO)OC[C@@](O)(CO)OC1

InChI

InChI=1S/C6H12O6/c7-1-5(9)3-12-6(10,2-8)4-11-5/h7-10H,1-4H2

InChIKey

KEQUNHIAUQQPAC-UHFFFAOYSA-N

LogP

-2.6049999999999995

Topological Polar Surface Area

99.38000000000001 Å²

Hydrogen Bond Donor/Acceptor

4 / 6

Complexity

144

Safety Information

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GHS Hazard Pictograms

H315

H319

H335

Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Stability

Stable. Incompatible with strong oxidizing agents. Protect from moisture.

Sensitiveness

Hygroscopic

Synonyms & References

English

1,3-Dihydroxyacetone dimer
(2R,5S)-Dihydroxy-1,4-dioxane-2,5-methanol
2,5-Dihydroxy-1,4-dioxane-2,5-dimethanol
Dihydroxyacetone dimer
2,5-Dihydroxydioxane-2,5-dimethanol
1,3-Dihydroxyacetone
1,3-DihydroxydiMethyl ketone
DHA Dimer
KetochroMin
Protosol
1，3-Dihydroxyacetone dimmer
trans-2,5-Bis(hydroxymethyl)-1,4-dioxane-2,5-diol
(2R,5S)-2,5-bis(hydroxymethyl)-1,4-dioxane-2,5-diol
trans-2,5-Dihydroxy-1,4-Dioxane-2,5-dimethanol
1,4-Dioxane-2,5-dimethanol, 2,5-dihydroxy-, trans-
(2R)-2,5-Dihydroxy-1,4-dioxane-2alpha,5beta-dimethanol
1,4-Dioxane-2,5-dimethanol,2,5-dihydroxy-, (2R,5S)-rel-
1,4-Dioxane-2,5- dimethanol, 2,5-dihydroxy-, (2R,5S)-rel-

MDL Number

MFCD00051019

Customs Code

2934999090

FAQ

What are the physical and chemical properties of 2,5-Bis(hydroxymethyl)-1,4-dioxane-2,5-diol (CAS: 62147-49-3)?

2,5-Bis(hydroxymethyl)-1,4-dioxane-2,5-diol is a colorless or pale yellow liquid at room temperature. It has a molecular weight of approximately 134.13 g/mol and a density of around 1.03 g/cm³. The compound is highly soluble in water and ethanol, and it is moderately reactive with aldehydes and ketones. It is also known for its ability to form stable cyclic structures and act as a good solvent.

How is 2,5-Bis(hydroxymethyl)-1,4-dioxane-2,5-diol (CAS: 62147-49-3) typically synthesized?

2,5-Bis(hydroxymethyl)-1,4-dioxane-2,5-diol can be synthesized via the condensation of formaldehyde and ethylene glycol, often using a catalyst such as hydroquinone to improve selectivity and yield. The reaction typically involves mixing the reactants and heating under controlled conditions to ensure the desired product is formed.

What industries use 2,5-Bis(hydroxymethyl)-1,4-dioxane-2,5-diol (CAS: 62147-49-3)?

2,5-Bis(hydroxymethyl)-1,4-dioxane-2,5-diol is widely used in the pharmaceutical industry as a stabilizer and solvent. It is also utilized in the polymer industry for modifying properties of polymers, in the sensor industry for detection applications, and in the semiconductor industry for cleaning solutions and etching processes.

What precautions should be taken when handling 2,5-Bis(hydroxymethyl)-1,4-dioxane-2,5-diol (CAS: 62147-49-3)?

When handling 2,5-Bis(hydroxymethyl)-1,4-dioxane-2,5-diol, it is essential to use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or fume hood. Spills should be handled with caution using appropriate absorbents, and the area should be thoroughly cleaned. Refer to the Material Safety Data Sheet (MSDS) for detailed information and emergency procedures.