3-(Hydroxymethyl)phenol

Basic Information

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CAS Number

620-24-6

Molecular Formula

C7H8O2

Molecular Weight

124.14 g/mol

EINECS

210-633-6

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Hydrocarbons

Basic Physical Properties

Physical State

Pink or beige to brown

Melting Point

69-72 °C

Boiling Point

300°C

Density

1,16 g/cm3

Water Solubility

soluble

Flash Point

300°C

Solubility

DMSO (Slightly), Methanol (Slightly)

Refractive Index

1.5035 (estimate)

SMILES

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C1=CC(=CC(=C1)O)CO

InChI

InChI=1S/C7H8O2/c8-5-6-2-1-3-7(9)4-6/h1-4,8-9H,5H2

InChIKey

OKVJCVWFVRATSG-UHFFFAOYSA-N

LogP

0.8844999999999998

pKa

pK1:9.83 (25°C)

Topological Polar Surface Area

40.46 Å²

Hydrogen Bond Donor/Acceptor

2 / 2

Complexity

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

Synonyms & References

English

3-hydroxybenzyl alcohol
3-(hydroxy)benzyl alcohol
UNII-H652F6XF7Y
DTXSID20211035
H652F6XF7Y
CHEBI:17069
3-hydroxymethyl phenol
AS-12681
FT-0615835
3-(Hydroxymethyl)phenol #
NSC60735
NSC-60735
CS-0008490
3-hydroxymethylphenol
MFCD00004643
HYDROXYBENZYL ALCOHOL, M-
3-Hydroxybenzyl alcohol, 99%
NS00014669
Benzyl alcohol, m-hydroxy-
InChI=1/C7H8O2/c8-5-6-2-1-3-7(9)4-6/h1-4,8-9H,5H
3-(Hydroxymethyl)phenol
Benzenemethanol, 3-hydroxy-
A833547
m-Hydroxybenzyl alcohol
620-24-6
AKOS000249424
[3,4,6-triacetoxy-5-(dimethylcarbamoylamino)tetrahydropyran-2-yl]methyl acetate;3-Hydroxybenzyl Alcohol
Z335245000
3-hydroxy benzyl alcohol
3-[(Hydroxy)methyl]phenol
NSC 60735

MDL Number

MFCD00004643

EC Number

210-633-6

Customs Code

29072900

FAQ

What are the physical and chemical properties of 3-(Hydroxymethyl)phenol (CAS: 620-24-6)?

3-(Hydroxymethyl)phenol (CAS: 620-24-6) is a white crystalline solid with a molecular weight of approximately 122.12 g/mol. Its solubility in water is 33.3 g/L at 20°C. Chemically, it is reactive towards acids and bases, forming salts or esters. It is also sensitive to light and air oxidation.

How is 3-(Hydroxymethyl)phenol (CAS: 620-24-6) typically synthesized?

3-(Hydroxymethyl)phenol is commonly synthesized from phenol through a Grignard reaction. A phenol derivative is reacted with magnesium in anhydrous ether to form a Grignard reagent, which is then reacted with formaldehyde to produce 3-(hydroxymethyl)phenol. The yield is typically around 70-80%, with the use of boron trifluoride as a Lewis acid catalyst to enhance the reaction selectivity.

What industries use 3-(Hydroxymethyl)phenol (CAS: 620-24-6)?

3-(Hydroxymethyl)phenol (CAS: 620-24-6) is used in various industries. It is a key intermediate in the synthesis of pharmaceuticals, particularly those involving antifungal and antiviral drugs. Additionally, it has applications in the production of polymer intermediates, as a component in dye-making processes, and in the development of sensor technologies.

What precautions should be taken when handling 3-(Hydroxymethyl)phenol (CAS: 620-24-6)?

When handling 3-(Hydroxymethyl)phenol (CAS: 620-24-6), it is important to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a fume hood to minimize inhalation risks. Spills should be cleaned up using appropriate absorbent materials, and the area should be well ventilated. Always refer to the Safety Data Sheet (SDS) for detailed handling and disposal instructions.