3-(Hydroxymethyl)phenol(CAS: 620-24-6)

3-(Hydroxymethyl)phenol (CAS: 620-24-6) is a white crystalline solid with a molecular weight of approximately 122.12 g/mol. Its solubility in water is 33.3 g/L at 20°C. Chemically, it is reactive towards acids and bases, forming salts or esters. It is also sensitive to light and air oxidation.

3-(Hydroxymethyl)phenol is commonly synthesized from phenol through a Grignard reaction. A phenol derivative is reacted with magnesium in anhydrous ether to form a Grignard reagent, which is then reacted with formaldehyde to produce 3-(hydroxymethyl)phenol. The yield is typically around 70-80%, with the use of boron trifluoride as a Lewis acid catalyst to enhance the reaction selectivity.

3-(Hydroxymethyl)phenol (CAS: 620-24-6) is used in various industries. It is a key intermediate in the synthesis of pharmaceuticals, particularly those involving antifungal and antiviral drugs. Additionally, it has applications in the production of polymer intermediates, as a component in dye-making processes, and in the development of sensor technologies.

When handling 3-(Hydroxymethyl)phenol (CAS: 620-24-6), it is important to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a fume hood to minimize inhalation risks. Spills should be cleaned up using appropriate absorbent materials, and the area should be well ventilated. Always refer to the Safety Data Sheet (SDS) for detailed handling and disposal instructions.