6-Methyl-1H-indol-4-ol

Basic Information

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CAS Number

61545-41-3

Molecular Formula

C9H9NO

Molecular Weight

147.18 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

SMILES

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CC1=CC2=C(C=CN2)C(=C1)O

InChI

InChI=1S/C9H9NO/c1-6-4-8-7(2-3-10-8)9(11)5-6/h2-5,10-11H,1H3

InChIKey

RCSZVTPWGUPMNJ-UHFFFAOYSA-N

LogP

2.18192

Topological Polar Surface Area

36.019999999999996 Å²

Hydrogen Bond Donor/Acceptor

2 / 2

Complexity

149

Synonyms & References

English

6-Methyl-1H-indol-4-ol
1H-Indol-4-ol,6-methyl-
4-Hydroxy-6-methyl indole
1H-Indol-4-ol,6-methyl
6-Methyl-4-indolol
4-Hydroxy-6-methylindole
1H-Indol-4-ol, 6-methyl-
RCSZVTPWGUPMNJ-UHFFFAOYSA-N
9236AB
AK113477
6-methyl-1H-indol-4-ol
DB-072981
SCHEMBL8912714
AKOS006284181
MFCD07781528
I11446
DS-6281
61545-41-3
DTXSID40601555
CS-0187230

MDL Number

MFCD07781528

Customs Code

2933990090

FAQ

What are the physical and chemical properties of 6-Methyl-1H-indol-4-ol (CAS: 61545-41-3)?

6-Methyl-1H-indol-4-ol is an organic compound with a molecular weight of approximately 144.21 g/mol. It exists as a crystalline solid with a melting point of about 152-154°C. The compound is sparingly soluble in water but soluble in organic solvents like methanol and ethanol. It is moderately reactive, particularly towards electrophilic aromatic substitution reactions. Its solubility in water at 25°C is around 0.2 g/L.

How is 6-Methyl-1H-indol-4-ol (CAS: 61545-41-3) typically synthesized?

6-Methyl-1H-indol-4-ol can be synthesized through the reduction of 6-methyl-1H-indole-4-carbaldehyde using catalytic hydrogenation with a palladium catalyst. Alternatively, it can be prepared by the reduction of 6-methyl-1H-indole-4-carboxaldehyde. The yield and selectivity are typically high, and the method is efficient under mild conditions.

What industries use 6-Methyl-1H-indol-4-ol (CAS: 61545-41-3)?

6-Methyl-1H-indol-4-ol is utilized in the pharmaceutical industry for the synthesis of certain drugs. It serves as an intermediate in the production of indole derivatives, which have applications in the development of new medicines. Additionally, it finds use in the production of various chemical intermediates and in research related to organic synthesis and materials science.

What precautions should be taken when handling 6-Methyl-1H-indol-4-ol (CAS: 61545-41-3)?

When handling 6-Methyl-1H-indol-4-ol (CAS: 61545-41-3), proper personal protective equipment (PPE) such as gloves, goggles, and a laboratory coat should be worn. Work should be conducted in a well-ventilated area or a fume hood to prevent inhalation. Spills should be cleaned up immediately using appropriate absorbent materials, and the area should be well-ventilated. Always consult the Material Safety Data Sheet (MSDS) for detailed safety information and emergency procedures.