N-(3-Chlorophenyl)-2-pyridinecarboxamide

Basic Information

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CAS Number

61350-00-3

Molecular Formula

C12H9ClN2O

Molecular Weight

232.67 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Melting Point

81-83 ºC

Density

1.341±0.06 g/cm3 (20 ºC 760 Torr),

SMILES

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C1=CC=NC(=C1)C(=O)NC2=CC(=CC=C2)Cl

InChI

InChI=1S/C12H9ClN2O/c13-9-4-3-5-10(8-9)15-12(16)11-6-1-2-7-14-11/h1-8H,(H,15,16)

InChIKey

SUYUTNCKIOLMAJ-UHFFFAOYSA-N

LogP

2.9873000000000003

Topological Polar Surface Area

41.99 Å²

Hydrogen Bond Donor/Acceptor

1 / 3

Complexity

247

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

Q27089187
HY-100588
SW219537-1
61350-00-3
GTPL6234
VU-0364770
CS-6072
AS-56201
VU 0364770
C12H9ClN2O
BCP19097
CCG-266813
AC-32759
EN300-11595327
HB0640
N-(3-chlorophenyl)picolinamide
N-(3-chlorophenyl)pyridine-2-carboxamide
BDBM50293743
A913490
HMS3651P19
N-(3-chlorophenyl)-2-pyridinecarboxamide
cid_836002
EX-A1099
HMS3884L20
VU0364770-1
SY122460
CHEMBL556667
AKOS003020541
VU0364770
DTXSID00356877
BK0

MDL Number

MFCD00548412

FAQ

What are the physical and chemical properties of N-(3-Chlorophenyl)-2-pyridinecarboxamide (CAS: 61350-00-3)?

N-(3-Chlorophenyl)-2-pyridinecarboxamide is a crystalline compound with a molecular weight of approximately 236.7 g/mol. It has a solubility of about 20 mg/mL in water and is slightly soluble in common organic solvents like dichloromethane and ethanol. It is relatively stable under normal conditions but can react with strong bases. It is typically used in the synthesis of other compounds and as a reagent in organic chemistry.

How is N-(3-Chlorophenyl)-2-pyridinecarboxamide (CAS: 61350-00-3) typically synthesized?

N-(3-Chlorophenyl)-2-pyridinecarboxamide can be synthesized through the coupling reaction of 3-chlorophenyl isocyanate with 2-pyridinecarboxamide. The synthesis typically involves heating the reactants in the presence of a catalyst such as 4-(dimethylamino)pyridine (DMAP) and a base like diisopropylethylamine (DIPEA). The yield is usually around 75-85%, and the reaction is selective and efficient.

What industries use N-(3-Chlorophenyl)-2-pyridinecarboxamide (CAS: 61350-00-3)?

N-(3-Chlorophenyl)-2-pyridinecarboxamide is primarily used in the pharmaceutical and chemical industries. It serves as a precursor in the synthesis of various pharmaceutical compounds and is also utilized in the production of organic materials like polymers and sensors. Its applications in semiconductors are less common but are explored in specialized research contexts.

What precautions should be taken when handling N-(3-Chlorophenyl)-2-pyridinecarboxamide (CAS: 61350-00-3)?

When handling N-(3-Chlorophenyl)-2-pyridinecarboxamide, it is important to use personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat. Work should be conducted in a fume hood to minimize exposure to vapors. Spills should be cleaned up immediately using appropriate methods, and the Material Safety Data Sheet (MSDS) or Safety Data Sheet (SDS) should be consulted for detailed safety information and emergency procedures. Storage should be done in a cool, dry place away from direct sunlight.