2-(2-Propyn-1-yloxy)tetrahydro-2H-pyran

Basic Information

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CAS Number

6089-04-9

Molecular Formula

C8H12O2

Molecular Weight

16.04 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Nitriles

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

Physical State

Colorless to Yellow Liquid

Boiling Point

65°C/9mmHg

Density

0.997 g/mL at 25 °C

Refractive Index

n20/D 1.458(lit.)

SMILES

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C#CCOC1CCCCO1

InChI

InChI=1S/C8H12O2/c1-2-6-9-8-5-3-4-7-10-8/h1,8H,3-7H2

InChIKey

HQAXHIGPGBPPFU-UHFFFAOYSA-N

LogP

0.6361

Topological Polar Surface Area

0.0 Å²

Hydrogen Bond Donor/Acceptor

0 / 0

Complexity

133

Safety Information

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Hazard Statement

H226 Flammable liquid and vapor
Flammable liquids

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

Hazard Class

Class 3 Class 3

Synonyms & References

English

2-(Prop-2-yn-1-yloxy)tetrahydro-2H-pyran
Tetrahydro-2-(2-Propynyloxy)-2H-Pyran
2-(2-Propynyloxy)tetrahydropyran
2-(prop-2-ynyloxy)-tetrahydro-2H-pyran
2H-Pyran, tetrahydro-2-(2-propyn-1-yloxy)-
2-(2-Propynyloxy)tetrahydro-2H-pyran
2-prop-2-ynoxyoxane
Tetrahydro-2-(2-propynyloxy)pyran
Tetrahydropyran-2-yloxypropyne
Tetrahydropyranyl propargyl ether
2-Propargyloxane
2-(Propargyloxy)tetrahydropyran
Propargyl 2-tetrahydropyranyl ether
2H-Pyran, tetrahydro-2-(2-propynyloxy)-
Propargyl alcohol tetrahydropyranyl ether
3-(2'-Tetrahydropyranyloxy)propyne
2-Propynyl 2-pyranyl ether
1-(2'-Tetrahydropyranyloxy)-2-propyne
2-(prop-2-ynyloxy)tetrahydro-2H-pyran
propargyl tetrahydropyranyl ether
HQAXHIGPGBPPFU-UHFFFAOYSA-N
3-(Tetrahyd
pent-4-ynoic acid
TETRAHYDRO-2-(2-PROPYNYLOXY)-2H-PYRAN, 9 8%
2-Propynyl tetrahydro-2H-pyran-2-yl ether
Tetrahydro-2-(2-propynyloxy)-2H-pyran

MDL Number

MFCD00006604

Customs Code

2932999099

FAQ

What are the physical and chemical properties of 2-(2-Propyn-1-yloxy)tetrahydro-2H-pyran (CAS: 6089-04-9)?

2-(2-Propyn-1-yloxy)tetrahydro-2H-pyran is a white crystalline solid with a molecular weight of approximately 164.2 g/mol. It has a melting point of about 47-49°C and a boiling point of around 148-150°C. The compound is moderately soluble in organic solvents such as ethanol and acetone but slightly soluble in water. It is known for its reactivity, particularly towards nucleophilic addition and elimination reactions.

How is 2-(2-Propyn-1-yloxy)tetrahydro-2H-pyran (CAS: 6089-04-9) typically synthesized?

2-(2-Propyn-1-yloxy)tetrahydro-2H-pyran is typically synthesized via a Wittig reaction. The process involves the reaction of 2-bromoprop-2-yn-1-ol with a phosphorus ylide, such as phenyltriphenylphosphonium bromide, in an inert solvent like dichloromethane. The reaction yields the compound in good yield (up to 80%), with high regioselectivity.

What industries use 2-(2-Propyn-1-yloxy)tetrahydro-2H-pyran (CAS: 6089-04-9)?

2-(2-Propyn-1-yloxy)tetrahydro-2H-pyran is used in various industries. In pharmaceuticals, it serves as a precursor for synthesizing drug candidates. In the polymer industry, it is used as a monomer to produce functional polymers. Additionally, it has applications in the sensor industry for developing chemical sensors and in the semiconductor industry for photoresist materials.

What precautions should be taken when handling 2-(2-Propyn-1-yloxy)tetrahydro-2H-pyran (CAS: 6089-04-9)?

When handling 2-(2-Propyn-1-yloxy)tetrahydro-2H-pyran, proper personal protective equipment (PPE) should be worn, including safety goggles, gloves, and a lab coat. The compound should be stored in a cool, dry place, away from direct sunlight. Fume hoods should be used during preparation and handling to minimize exposure. In case of a spill, it should be carefully cleaned up using absorbent material, and proper disposal methods should be followed as outlined in the Material Safety Data Sheet (MSDS/SDS).