2-(2-Propyn-1-yloxy)tetrahydro-2H-pyran(CAS: 6089-04-9)

2-(2-Propyn-1-yloxy)tetrahydro-2H-pyran is a white crystalline solid with a molecular weight of approximately 164.2 g/mol. It has a melting point of about 47-49°C and a boiling point of around 148-150°C. The compound is moderately soluble in organic solvents such as ethanol and acetone but slightly soluble in water. It is known for its reactivity, particularly towards nucleophilic addition and elimination reactions.

2-(2-Propyn-1-yloxy)tetrahydro-2H-pyran is typically synthesized via a Wittig reaction. The process involves the reaction of 2-bromoprop-2-yn-1-ol with a phosphorus ylide, such as phenyltriphenylphosphonium bromide, in an inert solvent like dichloromethane. The reaction yields the compound in good yield (up to 80%), with high regioselectivity.

2-(2-Propyn-1-yloxy)tetrahydro-2H-pyran is used in various industries. In pharmaceuticals, it serves as a precursor for synthesizing drug candidates. In the polymer industry, it is used as a monomer to produce functional polymers. Additionally, it has applications in the sensor industry for developing chemical sensors and in the semiconductor industry for photoresist materials.

When handling 2-(2-Propyn-1-yloxy)tetrahydro-2H-pyran, proper personal protective equipment (PPE) should be worn, including safety goggles, gloves, and a lab coat. The compound should be stored in a cool, dry place, away from direct sunlight. Fume hoods should be used during preparation and handling to minimize exposure. In case of a spill, it should be carefully cleaned up using absorbent material, and proper disposal methods should be followed as outlined in the Material Safety Data Sheet (MSDS/SDS).