1H-pyrrolo[3,2-c]pyridin-4-amine

Basic Information

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CAS Number

60290-23-5

Molecular Formula

C7H7N3

Molecular Weight

133.15 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

Boiling Point

388.5°C at 760 mmHg

Density

1.367

Flash Point

217.1 °C

Refractive Index

1.78

SMILES

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Nc1nccc2[nH]ccc12

InChI

InChI=1S/C7H7N3/c8-7-5-1-3-9-6(5)2-4-10-7/h1-4,9H,(H2,8,10)

InChIKey

AXIMEEWBBDTVHN-UHFFFAOYSA-N

LogP

1.1451

Topological Polar Surface Area

54.699999999999996 Å²

Hydrogen Bond Donor/Acceptor

3 / 3

Complexity

126

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H332 Harmful if inhaled
Acute toxicity, inhalation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

1H-Pyrrolo[3,2-c]pyridin-4-amine
4-Amino-5-azaindole
1H-pyrrolo[3,2-c]pyridin-4-ylamine
4-Amino-5-aza-indol
4-amino-1H-pyrrolo[3,2-c]pyridine
NSC289357
FCH862472
BC656113
SY026009
AX8093915
ST24038309
1H-pyrrolo[3,2-c]pyridin-4-amine

MDL Number

MFCD08690132

Customs Code

2933990090

FAQ

What are the physical and chemical properties of 1H-pyrrolo[3,2-c]pyridin-4-amine (CAS: 60290-23-5)?

1H-pyrrolo[3,2-c]pyridin-4-amine is a crystalline solid with a molecular weight of approximately 182.21 g/mol. It has a low water solubility and is moderately soluble in common organic solvents. This compound exhibits good stability in acidic and neutral conditions but is less stable in basic environments. It is an amine, which makes it reactive towards electrophiles.

How is 1H-pyrrolo[3,2-c]pyridin-4-amine (CAS: 60290-23-5) typically synthesized?

1H-pyrrolo[3,2-c]pyridin-4-amine can be synthesized through several routes. Common methods include the condensation of 3-pyridyl hydrazine with 1-pyridinecarboxaldehyde followed by amination. This process typically involves a palladium-catalyzed coupling reaction and provides a yield of around 70-80%, depending on the purity of starting materials and reaction conditions.

What industries use 1H-pyrrolo[3,2-c]pyridin-4-amine (CAS: 60290-23-5)?

1H-pyrrolo[3,2-c]pyridin-4-amine is used in various industries. It is a key intermediate in the development of pharmaceuticals, particularly in the synthesis of drugs targeting the nervous system. It also finds applications in the production of certain types of polymers and sensors, due to its unique chemical properties.

What precautions should be taken when handling 1H-pyrrolo[3,2-c]pyridin-4-amine (CAS: 60290-23-5)?

When handling 1H-pyrrolo[3,2-c]pyridin-4-amine, it is essential to use personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to minimize inhalation risks. Spills should be cleaned up using appropriate absorbent materials and disposed of according to local regulations. Safety data sheets (SDS) should be consulted for detailed handling and emergency procedures.