1H-pyrrolo[3,2-c]pyridin-4-amine(CAS: 60290-23-5)

1H-pyrrolo[3,2-c]pyridin-4-amine is a crystalline solid with a molecular weight of approximately 182.21 g/mol. It has a low water solubility and is moderately soluble in common organic solvents. This compound exhibits good stability in acidic and neutral conditions but is less stable in basic environments. It is an amine, which makes it reactive towards electrophiles.

1H-pyrrolo[3,2-c]pyridin-4-amine can be synthesized through several routes. Common methods include the condensation of 3-pyridyl hydrazine with 1-pyridinecarboxaldehyde followed by amination. This process typically involves a palladium-catalyzed coupling reaction and provides a yield of around 70-80%, depending on the purity of starting materials and reaction conditions.

1H-pyrrolo[3,2-c]pyridin-4-amine is used in various industries. It is a key intermediate in the development of pharmaceuticals, particularly in the synthesis of drugs targeting the nervous system. It also finds applications in the production of certain types of polymers and sensors, due to its unique chemical properties.

When handling 1H-pyrrolo[3,2-c]pyridin-4-amine, it is essential to use personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to minimize inhalation risks. Spills should be cleaned up using appropriate absorbent materials and disposed of according to local regulations. Safety data sheets (SDS) should be consulted for detailed handling and emergency procedures.