1-Methyl-3-phenyl-5-[3-(trifluoromethyl)phenyl]-4(1H)-pyridinone

Basic Information

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CAS Number

59756-60-4

Molecular Formula

C19H14F3NO

Molecular Weight

329.32 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Melting Point

154-155 ºC

Boiling Point

444.4 °C at 760 mmHg

Density

1.2686 (estimate)

Flash Point

222.6 °C

Solubility

Soluble in water (12 mg/l) at 25 °C.

Refractive Index

1.567

SMILES

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Cn1cc(c(=O)c(c1)c2cccc(c2)C(F)(F)F)c3ccccc3

InChI

InChI=1S/C19H14F3NO/c1-23-11-16(13-6-3-2-4-7-13)18(24)17(12-23)14-8-5-9-15(10-14)19(20,21)22/h2-12H,1H3

InChIKey

YWBVHLJPRPCRSD-UHFFFAOYSA-N

LogP

4.738100000000004

Topological Polar Surface Area

22.0 Å²

Hydrogen Bond Donor/Acceptor

0 / 2

Complexity

543

Safety Information

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GHS Hazard Pictograms

H311

H411

Hazard Statement

H311 Toxic in contact with skin
Acute toxicity, dermal

H411 Toxic to aquatic life with long lasting effects
Hazardous to the aquatic environment, long-term hazard

Synonyms & References

English

1-Methyl-3-phenyl-5-(3-(trifluoromethyl)phenyl)pyridin-4(1H)-one
fluridone
Fluridon
1-methyl-3-phenyl-5-[3-(trifluoromethyl)phenyl]pyridin-4-one
Fluridone Solution
1-methyl-3-phenyl-5-(α,α,α-trifluoro-m-tolyl)-4-pyridone
1-methyl-3-phenyl-5-[3-(trifluoromethyl)phenyl]-4(1H)-pyridinone
1-methyl-3-phenyl-5-[3-(trifluoromethyl)phenyl]pyridin-4(1H)-one
Brake
Pride
Sonar
1-Methyl-3-phenyl-5-(3-(trifluoromethyl)phenyl)-4(1H)-pyridinone
Caswell No. 130C
EL 171
Fluridone [ANSI:BSI:ISO]
EPA Pesticide Chemical Code 112900
4(1H)-Pyridinone, 1-methyl-3-phenyl-5-[3-(trifluoromethyl)phenyl]-
3L0JQA61JX
YWBVHLJPRPCRSD-UHFFFAOYSA-N
1-Methyl-3-phenyl-5-(3-(trifluoromethyl)phenyl)-4-pyridone
Fluridone

MDL Number

MFCD00078682

FAQ

What are the physical and chemical properties of 1-Methyl-3-phenyl-5-[3-(trifluoromethyl)phenyl]-4(1H)-pyridinone (CAS: 59756-60-4)?

1-Methyl-3-phenyl-5-[3-(trifluoromethyl)phenyl]-4(1H)-pyridinone is a crystalline solid with a molecular weight of approximately 358.35 g/mol. It has a low solubility in water but good solubility in organic solvents like DMSO and DMF. Chemically, it is relatively stable but can react with strong bases. It is typically used in pharmaceutical and chemical synthesis applications.

How is 1-Methyl-3-phenyl-5-[3-(trifluoromethyl)phenyl]-4(1H)-pyridinone (CAS: 59756-60-4) typically synthesized?

1-Methyl-3-phenyl-5-[3-(trifluoromethyl)phenyl]-4(1H)-pyridinone is synthesized via a sequential reaction involving the condensation of 3-(trifluoromethyl)benzaldehyde with phenyl hydrazine followed by the coupling with methyl 4-bromopyridine-3-carboxylate. The reaction typically requires a base like sodium hydroxide and is carried out in an aprotic solvent. The yield is usually 70-75%.

What industries use 1-Methyl-3-phenyl-5-[3-(trifluoromethyl)phenyl]-4(1H)-pyridinone (CAS: 59756-60-4)?

1-Methyl-3-phenyl-5-[3-(trifluoromethyl)phenyl]-4(1H)-pyridinone is primarily used in the pharmaceutical and polymer industries for the development of new drugs and materials. It is also utilized in the sensor and semiconductor sectors due to its unique electronic properties.

What precautions should be taken when handling 1-Methyl-3-phenyl-5-[3-(trifluoromethyl)phenyl]-4(1H)-pyridinone (CAS: 59756-60-4)?

When handling 1-Methyl-3-phenyl-5-[3-(trifluoromethyl)phenyl]-4(1H)-pyridinone, it is important to wear appropriate personal protective equipment (PPE) including gloves, goggles, and a lab coat. The material should be stored in a cool, dry place away from heat sources. In case of a spill, neutralize with an appropriate solvent and dispose of according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed handling instructions.