Compound Q&A
How is 1-Methyl-3-phenyl-5-[3-(trifluoromethyl)phenyl]-4(1H)-pyridinone (CAS: 59756-60-4) typically synthesized?
Answer
![1-Methyl-3-phenyl-5-[3-(trifluoromethyl)phenyl]-4(1H)-pyridinone](https://static.chemtradehub.com/structs/597/59756-60-4-f425.webp "1-Methyl-3-phenyl-5-[3-(trifluoromethyl)phenyl]-4(1H)-pyridinone")
1-Methyl-3-phenyl-5-[3-(trifluoromethyl)phenyl]-4(1H)-pyridinone is synthesized via a sequential reaction involving the condensation of 3-(trifluoromethyl)benzaldehyde with phenyl hydrazine followed by the coupling with methyl 4-bromopyridine-3-carboxylate. The reaction typically requires a base like sodium hydroxide and is carried out in an aprotic solvent. The yield is usually 70-75%.
About
CAS No
59756-60-4
English Name
1-Methyl-3-phenyl-5-[3-(trifluoromethyl)phenyl]-4(1H)-pyridinone
Molecular Formula
C19H14F3NO
Molecular Weight
329.32 g/mol
SMILES
Cn1cc(c(=O)c(c1)c2cccc(c2)C(F)(F)F)c3ccccc3
InChIKey
YWBVHLJPRPCRSD-UHFFFAOYSA-N
Last Updated: 2025-09-16 13:49
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