1-Methyl-3-phenyl-5-[3-(trifluoromethyl)phenyl]-4(1H)-pyridinone(CAS: 59756-60-4)

1-Methyl-3-phenyl-5-[3-(trifluoromethyl)phenyl]-4(1H)-pyridinone is a crystalline solid with a molecular weight of approximately 358.35 g/mol. It has a low solubility in water but good solubility in organic solvents like DMSO and DMF. Chemically, it is relatively stable but can react with strong bases. It is typically used in pharmaceutical and chemical synthesis applications.

1-Methyl-3-phenyl-5-[3-(trifluoromethyl)phenyl]-4(1H)-pyridinone is synthesized via a sequential reaction involving the condensation of 3-(trifluoromethyl)benzaldehyde with phenyl hydrazine followed by the coupling with methyl 4-bromopyridine-3-carboxylate. The reaction typically requires a base like sodium hydroxide and is carried out in an aprotic solvent. The yield is usually 70-75%.

1-Methyl-3-phenyl-5-[3-(trifluoromethyl)phenyl]-4(1H)-pyridinone is primarily used in the pharmaceutical and polymer industries for the development of new drugs and materials. It is also utilized in the sensor and semiconductor sectors due to its unique electronic properties.

When handling 1-Methyl-3-phenyl-5-[3-(trifluoromethyl)phenyl]-4(1H)-pyridinone, it is important to wear appropriate personal protective equipment (PPE) including gloves, goggles, and a lab coat. The material should be stored in a cool, dry place away from heat sources. In case of a spill, neutralize with an appropriate solvent and dispose of according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed handling instructions.