Biotin-PEG2-NHS ester

Basic Information

View in Editor

CAS Number

596820-83-6

Molecular Formula

C21H32N4O8S

Molecular Weight

500.57 g/mol

Basic Physical Properties

Density

1.37±0.1 g/cm3 (20 ºC 760 Torr),

SMILES

View in Editor

O=C(ON1C(CCC1=O)=O)CCOCCOCCNC(CCCCC2SCC(C2N3)NC3=O)=O

InChI

InChI=1S/C21H32N4O8S/c26-16(4-2-1-3-15-20-14(13-34-15)23-21(30)24-20)22-8-10-32-12-11-31-9-7-19(29)33-25-17(27)5-6-18(25)28/h14-15,20H,1-13H2,(H,22,26)(H2,23,24,30)

InChIKey

UCJSJBIJPAZUGU-UHFFFAOYSA-N

LogP

-0.14109999999999612

Topological Polar Surface Area

152.37 Å²

Hydrogen Bond Donor/Acceptor

3 / 12

Complexity

751

Synonyms & References

English

9-BiotinlaMino-4,7-dioxanonanoic acid N-hydroxysucciniMidyl ester
N-Succinimidyl 9-(Biotinamido)-4,7-dioxanonanoate
(+)-Biotin-PEG2-NHS Ester
9-(Biotinamido)-4,7-dioxanonanoic Acid N-Succinimidyl Ester
Biotin-PEG2-NHS
Biotin-PEG2-NHS ester
BIPG1228
S0955
9-Biotinylamino-4,7-dioxanonanoic acid n-hydroxysuccinimidyl ester

MDL Number

MFCD11974976

FAQ

What are the physical and chemical properties of Biotin-PEG2-NHS ester (CAS: 596820-83-6)?

Biotin-PEG2-NHS ester (CAS: 596820-83-6) is a crystalline compound with a molecular weight of approximately 421.44 g/mol. It is poorly soluble in water but soluble in organic solvents like DMSO and DMF. This compound is reactive towards amine groups and is commonly used for conjugation reactions. It exhibits good stability in anhydrous organic solvents and air, but hydrolysis may occur in aqueous solutions.

How is Biotin-PEG2-NHS ester (CAS: 596820-83-6) typically synthesized?

Biotin-PEG2-NHS ester (CAS: 596820-83-6) is synthesized through the reaction of biotin with PEG2-NHS ester. This process typically involves the coupling of biotin to the NHS ester moiety of PEG2 under anhydrous conditions to form the amide bond. The reaction is catalyzed by a base like triethylamine and proceeds with good selectivity and yield, usually 85-95%.

What industries use Biotin-PEG2-NHS ester (CAS: 596820-83-6)?

Biotin-PEG2-NHS ester (CAS: 596820-83-6) is widely used in the pharmaceutical industry for target labeling, in the polymer industry for functionalization and cross-linking, in the sensor industry for biosensing applications, and in the semiconductor industry for surface modification. It serves as a versatile linker for attaching biotin to various surfaces and biomolecules.

What precautions should be taken when handling Biotin-PEG2-NHS ester (CAS: 596820-83-6)?

When handling Biotin-PEG2-NHS ester (CAS: 596820-83-6), it is important to work in a fume hood to avoid inhalation of volatile components. Use personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Dispose of any waste in accordance with local regulations and consult the Safety Data Sheet (SDS) for specific disposal instructions. Avoid contact with skin and eyes, and wash hands thoroughly after use.