Fluoxetine hydrochloride

Basic Information

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CAS Number

59333-67-4

Molecular Formula

C17H19ClF3NO

Molecular Weight

345.8 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Ethers

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Melting Point

158-159°C

Flash Point

9℃

Solubility

H2O: 4 mg/mL

SMILES

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CNCCC(C1=CC=CC=C1)OC2=CC=C(C=C2)C(F)(F)F.Cl

InChI

InChI=1S/C17H18F3NO.ClH/c1-21-12-11-16(13-5-3-2-4-6-13)22-15-9-7-14(8-10-15)17(18,19)20;/h2-10,16,21H,11-12H2,1H3;1H

InChIKey

GIYXAJPCNFJEHY-UHFFFAOYSA-N

LogP

4.856800000000004

Topological Polar Surface Area

21.259999999999998 Å²

Hydrogen Bond Donor/Acceptor

1 / 2

Complexity

308

Safety Information

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Hazard Class

Class IRRITANT Class IRRITANT

Stability

Stable. Incompatible with strong oxidizing agents.

Toxicity

LD50 in mice, rats (mg/kg): 248, 452 orally (Stark)

Synonyms & References

English

Fluoxetine HCl
HMS1569H03
FLUOXETINE HYDROCHLORIDE [GREEN BOOK]
Framex
Methyl(3-phenyl-3-(4-(trifluoromethyl)phenoxy)propyl)ammonium chloride
CAS-56296-78-7
FLUOXETINE HYDROCHLORIDE (USP-RS)
AB04860
EINECS 260-101-2
(+-)-Methyl-gamma-(4-(trifluoromethyl)phenoxy)benzenepropanamine hydrochloride
methyl({3-phenyl-3-[4-(trifluoromethyl)phenoxy]propyl})amine hydrochloride
Fluox-Puren
F-132
Sanzur
Selfemra
CHEBI:145458
FT-0626490
(+/-)-N-METHYL-3-PHENYL-3-((.ALPHA.,.ALPHA.,.ALPHA.-TRIFLUORO-P-TOLYL)OXY)PROPYLAMINE, HYDROCHLORIDE
Pharmakon1600-01504173
HB1600
Alzac 20
BENZENEPROPANAMINE, N-METHYL-.GAMMA.-(4-(TRIFLUOROMETHYL)PHENOXY)-, HYDROCHLORIDE (1:1)
UNII-I9W7N6B1KJ
Nuzak
J-521372
MLS000069361
AKOS015894939
Fluoxetine Hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material
Fluoxetine hydrochloride 100 microg/mL in Acetonitrile
N-Methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propylamine Hydrochloride
Modipran

MDL Number

MFCD00214288

Customs Code

2922199090

FAQ

What are the physical and chemical properties of Fluoxetine hydrochloride (CAS: 59333-67-4)?

Fluoxetine hydrochloride is a white or slightly yellow crystalline powder with a molecular weight of 309.68 g/mol. It is sparingly soluble in water and readily soluble in dilute hydrochloric acid. Chemically, it is stable under normal storage conditions but can undergo hydrolysis under acidic or basic conditions.

How is Fluoxetine hydrochloride (CAS: 59333-67-4) typically synthesized?

Fluoxetine hydrochloride is synthesized through a multi-step process starting with fluvoxamine. The key steps involve the conversion of fluvoxamine to fluoxetine, followed by the chloride formation using hydrochloric acid. The reaction is typically carried out in a solvent such as ethanol under mild conditions.

What industries use Fluoxetine hydrochloride (CAS: 59333-67-4)?

Fluoxetine hydrochloride is primarily used in the pharmaceutical industry as an antidepressant. It is also used in veterinary medicine for treating certain behavioral disorders in animals. Some research applications involve its use in studying serotonin reuptake inhibition.

What precautions should be taken when handling Fluoxetine hydrochloride (CAS: 59333-67-4)?

When handling Fluoxetine hydrochloride, ensure proper personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Store it in a dry, cool place away from direct sunlight. Use a fume hood for any manipulations to avoid inhalation of dust. Always refer to the material safety data sheet (MSDS/SDS) for detailed safety guidelines.