1H-Imidazole-4-sulfonyl chloride

Basic Information

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CAS Number

58767-51-4

Molecular Formula

C3H3ClN2O2S

Molecular Weight

166.59 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Agricultural Chemicals Pesticides Herbicides

Water Treatment Chemicals Coagulants and Flocculants Inorganic Coagulants

Water Treatment Chemicals Disinfectants Chlorine Compounds

Basic Physical Properties

Physical State

Solid

Melting Point

163-174 °C

Boiling Point

418.2℃ at 760 mmHg

Water Solubility

Slightly soluble in water.

SMILES

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ClS(=O)(=O)c1c[nH]cn1

InChI

InChI=1S/C3H3ClN2O2S/c4-9(7,8)3-1-5-2-6-3/h1-2H,(H,5,6)

InChIKey

MXCZCMCHRWGSBX-UHFFFAOYSA-N

LogP

0.33720000000000006

Topological Polar Surface Area

62.82 Å²

Hydrogen Bond Donor/Acceptor

1 / 4

Safety Information

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GHS Hazard Pictograms

H314

Hazard Statement

H314 Causes severe skin burns and eye damage
Skin corrosion/irritation

Hazard Class

Class 8 Class 8

Sensitiveness

Moisture Sensitive

Synonyms & References

English

Imidazole-4-sulfonyl chloride
1H-Imidazole-4-sulfonyl chloride
1(3)H-imidazole-4-sulfonyl chloride
4(5)-imidazolesulfonyl chloride
4-imidazolesulfonyl chloride
BB_SC-5330
BBL011082
CTK5A8845
imidazole-4-sulphonyl chloride
PubChem19106
SC3421
STK802292

MDL Number

MFCD08687938

FAQ

What are the physical and chemical properties of 1H-Imidazole-4-sulfonyl chloride (CAS: 58767-51-4)?

1H-Imidazole-4-sulfonyl chloride is a white crystalline solid with a molecular weight of 193.57 g/mol. It is poorly soluble in water but soluble in organic solvents such as dichloromethane and acetonitrile. The compound is moderately reactive, particularly with amines and thiols, leading to the formation of corresponding sulfonamides. It is used in various synthetic applications due to its reactivity and selective nature.

How is 1H-Imidazole-4-sulfonyl chloride (CAS: 58767-51-4) typically synthesized?

1H-Imidazole-4-sulfonyl chloride is commonly synthesized via the reaction of 4-(chlorosulfonyl)benzenesulfonamide with imidazole in the presence of a base like sodium hydride or potassium carbonate. The yield is typically around 80%, and the method involves careful control of the reaction conditions to achieve high selectivity and purity.

What industries use 1H-Imidazole-4-sulfonyl chloride (CAS: 58767-51-4)?

1H-Imidazole-4-sulfonyl chloride is primarily used in the pharmaceutical and chemical industry for its reactivity in organic synthesis. It is also utilized in the production of functional polymers, sensors, and in the development of certain semiconductors due to its unique chemical properties and ability to form stable derivatives.

What precautions should be taken when handling 1H-Imidazole-4-sulfonyl chloride (CAS: 58767-51-4)?

When handling 1H-Imidazole-4-sulfonyl chloride, it is essential to use proper personal protective equipment (PPE), including gloves, safety goggles, and lab coat. The compound should be stored in a well-ventilated area and preferably in a fume hood to minimize exposure. In case of a spill, handle it carefully and dispose of according to local regulations. Always refer to the Material Safety Data Sheet (MSDS) for detailed safety information.