4-Pyridinylmethanol

Basic Information

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CAS Number

586-95-8

Molecular Formula

C6H7NO

Molecular Weight

109.13 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

Physical State

Solid

Melting Point

52-56 °C

Boiling Point

107-110 °C/1 mmHg

Refractive Index

1.5040 (estimate)

SMILES

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C1=CN=CC=C1CO

InChI

InChI=1S/C6H7NO/c8-5-6-1-3-7-4-2-6/h1-4,8H,5H2

InChIKey

PTMBWNZJOQBTBK-UHFFFAOYSA-N

LogP

0.5739

Topological Polar Surface Area

33.120000000000005 Å²

Hydrogen Bond Donor/Acceptor

1 / 2

Complexity

59.5

Safety Information

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GHS Hazard Pictograms

H302

H315

H319

H335

Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Hazard Class

Class IRRITANT Class IRRITANT

Class HYGROSCOPIC Class HYGROSCOPIC

Class KEEP COLD Class KEEP COLD

Sensitiveness

Hygroscopic

Synonyms & References

English

InChI=1/C6H7NO/c8-5-6-1-3-7-4-2-6/h1-4,8H,5H
PY7
gamma-Picolyl alcohol
DTXSID90870638
pyridin-4-ylmethanol;Pyridine-4-methanol
pyridine-4-ylmethanol
NSC-49167
Q27464630
4-hydroxymethyl-pyridine
586-95-8
Pyridine-4-yl-methanol
AS-12010
AKOS000248904
4-Pyridylcarbinol
4-Pyridinylmethanol
pyridine-4ylmethanol
SY003306
Pyridine-4-methanol
FT-0619452
4-pyridine methanol
4-PYRIDINEMETHANOL
(4-pyridyl)methanol
F0001-1532
4-pyridine-methanol
4-HYDROMETHYL PYRIDINE
CS-W007605
NSC-26024
MFCD00006442
A8295
4-Pyridylmethanol
SCHEMBL11484804

MDL Number

MFCD00006442

Customs Code

29333999

FAQ

What are the physical and chemical properties of 4-Pyridinylmethanol (CAS: 586-95-8)?

4-Pyridinylmethanol (CAS: 586-95-8) is a colorless to slightly yellow liquid with a molecular weight of 119.13 g/mol. It has a pKa of 12.9 and a boiling point of 253°C. The compound is poorly soluble in water but soluble in ethanol and chloroform. It is moderately reactive, particularly with acids and bases, and can undergo typical alcohol reactions such as esterification and alkylation.

How is 4-Pyridinylmethanol (CAS: 586-95-8) typically synthesized?

4-Pyridinylmethanol is typically synthesized by reducing 4-pyridinemethanone with sodium borohydride. The key steps involve the reduction of the ketone functional group to form the alcohol. This process yields good selectivity and moderate to high yield, depending on the reaction conditions and catalysts used.

What industries use 4-Pyridinylmethanol (CAS: 586-95-8)?

4-Pyridinylmethanol (CAS: 586-95-8) is used in various industries, including pharmaceuticals, where it serves as a precursor to drug synthesis, and in the chemical synthesis of polymers and sensors. Its functionality as an alcohol makes it useful in developing materials with specific reactivity and solubility properties.

What precautions should be taken when handling 4-Pyridinylmethanol (CAS: 586-95-8)?

Proper safety measures should be taken when handling 4-Pyridinylmethanol (CAS: 586-95-8) due to its reactivity and potential health risks. Use personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work in a well-ventilated area or fume hood to avoid inhalation. Store in a cool, dry place away from heat sources. In case of spill, refer to the safety data sheet (SDS) for appropriate cleanup procedures.