(11beta,16alpha)-9-Chloro-11,17-dihydroxy-16-methylpregna-1,4-diene-3,20-dione | CAS No. 57780-86-6

(11beta,16alpha)-9-Chloro-11,17-dihydroxy-16-methylpregna-1,4-diene-3,20-dione

Basic Information

CAS Number

57780-86-6

Molecular Formula

C22H29ClO4

Molecular Weight

392.92 g/mol

AD

Basic Physical Properties

Physical State

White to Off-White

Melting Point

>255° (dec.)

Boiling Point

No data available

Density

No data available

Flash Point

No data available

Solubility

DMSO (Slightly)

Vapor Pressure

No data available

CC(=O)[C@@]1(O)[C@H](C)C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(Cl)[C@@H](O)C[C@]12C

InChI

InChI=1S/C22H29ClO4/c1-12-9-17-16-6-5-14-10-15(25)7-8-19(14,3)21(16,23)18(26)11-20(17,4)22(12,27)13(2)24/h7-8,10,12,16-18,26-27H,5-6,9,11H2,1-4H3/t12-,16+,17+,18+,19+,20+,21+,22+/m1/s1

InChIKey

PPHLHSSXDSBOAQ-QAHQDLQKSA-N

LogP

3.1926000000000014

Topological Polar Surface Area

74.6 Ų

Hydrogen Bond Donor/Acceptor

2 / 4

Safety Information

View Safety Information

Hazard Statement

Synonyms & References

English

  • Mometasone Furoate EP Impurity M
  • Mometasone Furoate Impurity 13(Mometasone Furoate EP Impurity M)
  • Mometasone Impurity M
  • Mometasone EP Impurity M
  • (8S,9R,10S,11S,13S,14S,16R,17R)-17-acetyl-9-chloro-11,17-dihydroxy-10,13,16-trimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one
  • (11β,16α)-9-Chloro-11,17-dihydroxy-16-methyl-pregna-1,4-diene-3,20-dione (Mometasone Impurity M)
  • 9-Chloro-11β,17-dihydroxy-16α-methylpregna-1,4-diene-3,20-dione

FAQ

What regulatory guidelines apply to (11beta,16alpha)-9-Chloro-11,17-dihydroxy-16-methylpregna-1,4-diene-3,20-dione (CAS: 57780-86-6)?

This compound is classified under GHS as a hazardous substance due to its potential toxicity. Regulatory guidelines include compliance with REACH regulations for registration, evaluation, authorization, and restriction of chemicals. FDA and EPA regulations may apply for its use in pharmaceuticals and environmental discharge, respectively. It is essential to adhere to local and international safety standards for handling and storage.

Are there alternatives to (11beta,16alpha)-9-Chloro-11,17-dihydroxy-16-methylpregna-1,4-diene-3,20-dione (CAS: 57780-86-6) in synthesis?

There are several alternatives that can be used in its synthesis, such as other steroids with similar functional groups or different chlorinated derivatives. Commonly, researchers may opt for analogs like (11beta,16alpha)-9-Chloro-11,17-dihydroxy-16-methylpregna-4-diene-3,20-dione or other alkylated or substituted steroids as practical alternatives. These alternatives offer similar structural features while potentially simplifying the synthesis process.

What is the market or research trend for (11beta,16alpha)-9-Chloro-11,17-dihydroxy-16-methylpregna-1,4-diene-3,20-dione (CAS: 57780-86-6)?

Market trends for this compound show increasing interest in its application in pharmaceutical research, particularly in the development of novel hormonal drugs. Research trends indicate a focus on exploring its potential as a sex hormone or its derivatives in various therapeutic areas. Additionally, there is a growing emphasis on understanding its pharmacological properties and safety profiles.

How should waste containing (11beta,16alpha)-9-Chloro-11,17-dihydroxy-16-methylpregna-1,4-diene-3,20-dione (CAS: 57780-86-6) be handled?

Waste containing this compound should be collected in appropriate containers, sealed, and labeled as hazardous. It should be stored in a secure, well-ventilated area away from ignition sources. Disposal should follow local regulations, often requiring incineration in an approved facility or professional waste disposal. Ensure that all handling procedures comply with safety and environmental protection guidelines to prevent exposure and environmental contamination.

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