4-Chloro-6-methoxy-2-pyrimidinamine

Basic Information

View in Editor

CAS Number

5734-64-5

Molecular Formula

C5H6ClN3O

Molecular Weight

159.58 g/mol

Basic Physical Properties

Melting Point

168.0 to 173.0 deg-C

Boiling Point

349.4°C at 760 mmHg

Flash Point

165.1℃

Refractive Index

1.4510 (estimate)

SMILES

View in Editor

COC1=CC(=NC(=N1)N)Cl

InChI

InChI=1S/C5H6ClN3O/c1-10-4-2-3(6)8-5(7)9-4/h2H,1H3,(H2,7,8,9)

InChIKey

VFEYBTFCBZMBAU-UHFFFAOYSA-N

LogP

0.7208000000000001

Topological Polar Surface Area

61.03 Å²

Hydrogen Bond Donor/Acceptor

2 / 4

Complexity

113

Safety Information

View Safety Information

GHS Hazard Pictograms

H302

Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

Hazard Class

Class IRRITANT Class IRRITANT

Synonyms & References

English

5734-64-5
SCHEMBL154744
2-Pyrimidinamine, 4-chloro-6-methoxy-
Pyrimidine, 2-amino-4-chloro-6-methoxy-
2-amino-4-chloro-6-methoxy-pyrimidine
EN300-103944
4-Chloro-6-methoxy-pyrimidin-2-ylamine
4-Chloro-6-methoxy-2-pyrimidinamine #
NSC-28420
A8173
NSC28420
CS-W002539
AC-3126
PS-3383
AM20100403
2-Amino-4-chloro-6-methoxypyrimidine
SB57288
SY003927
4-chloro-6-methoxypyrimidine-2-ylamine
MFCD00233535
NS00022405
FT-0635826
2-Amino-4-chloro-6-methoxypyrimidine, 95%
DTXSID7073357
AG-670/25003515
NSC 28420
W-203157
BDBM625963
2-amino-4-methoxy-6-chloro pyrimidine
4-Chloro-6-methoxy-2-pyrimidinamine
4-chloro-6-methoxypyrimidin-2-amine

MDL Number

MFCD00233535

Customs Code

2933599090

FAQ

What are the physical and chemical properties of 4-Chloro-6-methoxy-2-pyrimidinamine (CAS: 5734-64-5)?

4-Chloro-6-methoxy-2-pyrimidinamine is a white crystalline solid with a molecular weight of approximately 207.01 g/mol. It has a melting point of about 135-137°C and is slightly soluble in water. This compound is moderately reactive, particularly in the presence of bases and reducing agents. It is used in various chemical reactions due to its functional groups.

How is 4-Chloro-6-methoxy-2-pyrimidinamine (CAS: 5734-64-5) typically synthesized?

4-Chloro-6-methoxy-2-pyrimidinamine is typically synthesized via the reaction of 6-chloropyrimidine with methanol followed by treatment with sodium hydroxide. Commonly, this involves the condensation of 6-chloropyrimidine with methanol to form the 5-chloro-6-methoxypyrimidine, which is then reduced to the amine using a suitable reducing agent such as sodium borohydride.

What industries use 4-Chloro-6-methoxy-2-pyrimidinamine (CAS: 5734-64-5)?

4-Chloro-6-methoxy-2-pyrimidinamine is primarily used in the pharmaceutical industry for the synthesis of antiviral and antifungal drugs. It is also utilized in the production of intermediates for polymers and in the development of sensors and semiconductors due to its electronic properties.

What precautions should be taken when handling 4-Chloro-6-methoxy-2-pyrimidinamine (CAS: 5734-64-5)?

When handling 4-Chloro-6-methoxy-2-pyrimidinamine, it is essential to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and laboratory coat. Work should be performed in a well-ventilated fume hood. Spills should be handled with caution, and the material safety data sheet (MSDS) should be consulted for specific cleanup procedures. This compound is hazardous if swallowed or inhaled, so avoid contact with skin and eyes.