4-Chloro-6-methoxy-2-pyrimidinamine(CAS: 5734-64-5)

4-Chloro-6-methoxy-2-pyrimidinamine is a white crystalline solid with a molecular weight of approximately 207.01 g/mol. It has a melting point of about 135-137°C and is slightly soluble in water. This compound is moderately reactive, particularly in the presence of bases and reducing agents. It is used in various chemical reactions due to its functional groups.

4-Chloro-6-methoxy-2-pyrimidinamine is typically synthesized via the reaction of 6-chloropyrimidine with methanol followed by treatment with sodium hydroxide. Commonly, this involves the condensation of 6-chloropyrimidine with methanol to form the 5-chloro-6-methoxypyrimidine, which is then reduced to the amine using a suitable reducing agent such as sodium borohydride.

4-Chloro-6-methoxy-2-pyrimidinamine is primarily used in the pharmaceutical industry for the synthesis of antiviral and antifungal drugs. It is also utilized in the production of intermediates for polymers and in the development of sensors and semiconductors due to its electronic properties.

When handling 4-Chloro-6-methoxy-2-pyrimidinamine, it is essential to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and laboratory coat. Work should be performed in a well-ventilated fume hood. Spills should be handled with caution, and the material safety data sheet (MSDS) should be consulted for specific cleanup procedures. This compound is hazardous if swallowed or inhaled, so avoid contact with skin and eyes.