Avatrombopag | CAS No. 570406-98-3

Avatrombopag

Basic Information

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CAS Number

570406-98-3

Molecular Formula

C29H34Cl2N6O3S2

Molecular Weight

649.67 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Agricultural Chemicals Pesticides Herbicides

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Density

1.440

SMILES

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C1CCC(CC1)N2CCN(CC2)C3=C(N=C(S3)NC(=O)C4=CC(=C(N=C4)N5CCC(CC5)C(=O)O)Cl)C6=CC(=CS6)Cl

InChI

InChI=1S/C29H34Cl2N6O3S2/c30-20-15-23(41-17-20)24-27(37-12-10-35(11-13-37)21-4-2-1-3-5-21)42-29(33-24)34-26(38)19-14-22(31)25(32-16-19)36-8-6-18(7-9-36)28(39)40/h14-18,21H,1-13H2,(H,39,40)(H,33,34,38)

InChIKey

OFZJKCQENFPZBH-UHFFFAOYSA-N

LogP

6.581400000000007

Topological Polar Surface Area

101.89999999999999 Å²

Hydrogen Bond Donor/Acceptor

2 / 9

Complexity

935

Safety Information

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Hazard Statement

H317 May cause an allergic skin reaction
Sensitization, Skin

H319 Causes serious eye irritation
Serious eye damage/eye irritation

Synonyms & References

English

Avatrombopag
1-(3-Chlor-5-{[4-(4-chlor-2-thienyl)-5-(4-cyclohexyl-1-piperazinyl)-1,3-thiazol-2-yl]carbamoyl}-2-pyridinyl)-4-piperidincarbons�ure [German]
1-(3-Chloro-5-{[4-(4-chloro-2-thienyl)-5-(4-cyclohexyl-1-piperazinyl)-1,3-thiazol-2-yl]carbamoyl}-2-pyridinyl)-4-piperidinecarboxylic acid
1-(3-chloro-5-{[4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-yl]carbamoyl}pyridin-2-yl)piperidine-4-carboxylic acid
4-Piperidinecarboxylic acid, 1-[3-chloro-5-[[[4-(4-chloro-2-thienyl)-5-(4-cyclohexyl-1-piperazinyl)-2-thiazolyl]amino]carbonyl]-2-pyridinyl]-
E-5501
1-[3-chloro-5-[[4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)-1,3-thiazol-2-yl]carbamoyl]pyridin-2-yl]piperidine-4-carboxylic acid
AKR 501
AKR-501
AS1670542
E5501
UNII-3H8GSZ4SQL
YM477
1-[3-Chloro-5-[[4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-yl]carbamoyl]-2-pyridyl]piperidine-4-carboxylic acid
1-(3-chloro-5-((4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-yl)carbamoyl)pyridin-2-yl)piperidine-4-carboxylic acid
NS00072948
avatrombopagum
SB16846
Avatrombopag (AKR-501)
DTXSID30205667
E5501 compound
SCHEMBL289354
Avatrombopag free base
HY-13463
F85065
AS 1670542
3H8GSZ4SQL
YM 477
Q27257213
GLXC-10486
D10306

MDL Number

MFCD18633249

FAQ

What regulatory guidelines apply to Avatrombopag (CAS: 570406-98-3)?

Avatrombopag (CAS: 570406-98-3) is subject to various regulatory guidelines including the Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH) in the European Union, and the U.S. Food and Drug Administration (FDA) and Environmental Protection Agency (EPA) requirements for pharmaceuticals. It is essential to comply with these regulations for manufacturing, distribution, and usage.

Are there alternatives to Avatrombopag (CAS: 570406-98-3) in synthesis?

Avatrombopag (CAS: 570406-98-3) has several analogs and structural isomers that can serve as alternatives in synthesis. Common alternatives include TPO agonists with similar mechanisms of action, such as eltrombopag and crizotinib, which can be used as substitutes depending on the specific requirements of the synthesis.

What is the market or research trend for Avatrombopag (CAS: 570406-98-3)?

The market for Avatrombopag (CAS: 570406-98-3) is driven by growing demand in the treatment of thrombocytopenia. Research trends focus on its efficacy and safety in various clinical settings, including its use in hematological disorders and post-surgical conditions. Market trends indicate increasing interest in this TPO agonist as a therapeutic option.

How should waste containing Avatrombopag (CAS: 570406-98-3) be handled?

Waste containing Avatrombopag (CAS: 570406-98-3) should be collected in appropriate containers and handled according to local waste disposal regulations. Incineration or professional waste disposal services are recommended to ensure environmental safety. Proper labeling and documentation of waste disposal processes are also critical to comply with environmental protection standards.