Cefazolin Impurity C

Basic Information

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CAS Number

56842-77-4

Molecular Formula

C11H12N6O4S

Molecular Weight

324.32 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Basic Physical Properties

Density

1.93±0.1 g/cm3 (20 ºC 760 Torr),

SMILES

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CC1=C(N2C(C(C2=O)NC(=O)CN3C=NN=N3)SC1)C(=O)O

InChI

InChI=1S/C11H12N6O4S/c1-5-3-22-10-7(9(19)17(10)8(5)11(20)21)13-6(18)2-16-4-12-14-15-16/h4,7,10H,2-3H2,1H3,(H,13,18)(H,20,21)/t7-,10-/m1/s1

InChIKey

DGYURGWZOSQCFG-GMSGAONNSA-N

LogP

-1.5683999999999991

Topological Polar Surface Area

130.31 Å²

Hydrogen Bond Donor/Acceptor

2 / 10

Complexity

567

Synonyms & References

English

Cefazolin Impurity C
7-[1-(1H)-Tetrazolylacetamido]-desacetoxycephalosporansaeure
(6R-trans)-3-Methyl-8-oxo-7-[(1H-tetrazol-1-ylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
(6R,7R)-7-(2-(1H-tetrazol-1-yl)acetamido)-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
(6R,7R)-7-(2-(1H-Tetrazol-1-yl)acetamido)-3-methyl-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid
F19295
(6R,7R)-3-METHYL-8-OXO-7-((1H-TETRAZOL-1-YLACETYL)AMINO)-5-THIA-1-AZABICYCLO(4.2.0)OCT-2-ENE-2-CARBOXYLIC ACID
AMY27768
(6R-trans)-3-methyl-8-oxo-7-[(1H-tetrazol-1-ylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, cefazolin sodium impurity C
UNII-PGB16683CG
(6R,7R)-7-(2-(1H-tetrazol-1-yl)acetamido)-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid
PD192451
5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 3-methyl-8-oxo-7-((1H-tetrazol-1-ylacetyl)amino)-, (6R-trans)-
7-(1-(1H)-Tetrazolylacetamido)deacetoxycephalosporanic acid
(6R,7R)-3-Methyl-8-oxo-7-[(1H-tetrazol-1-ylacetyl)amino]-5-thia-1-azabicyclo [4.2.0]oct-2-ene-2-carboxylic acid
7-[1-(1H)-Tetrazolylacetamido]desacetoxycephalosporanic Acid
(6R,7R)-3-methyl-8-oxo-7-[[2-(tetrazol-1-yl)acetyl]amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
PGB16683CG
7-(1-(1H)-Tetrazolylacetamido)desacetoxycephalosporanic acid
CEFAZOLIN SODIUM IMPURITY C [EP IMPURITY]
56842-77-4
(6R,7R)-3-methyl-8-oxo-7-[(1H-tetrazol-1-ylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

MDL Number

MFCD31560086

FAQ

What are the physical and chemical properties of Cefazolin Impurity C (CAS: 56842-77-4)?

Cefazolin Impurity C is a crystalline compound with a molecular weight of approximately 328.27 g/mol. It has a solubility of about 10 mg/mL in water and is less soluble in organic solvents. Chemically, it is slightly reactive towards bases and oxidizing agents. It is important to handle it under an inert atmosphere to avoid decomposition.

How is Cefazolin Impurity C (CAS: 56842-77-4) typically synthesized?

Cefazolin Impurity C is synthesized through a multistep process involving acylation, reduction, and amidation reactions. Commonly, anhydrous conditions and the use of a catalytic amount of a base such as sodium hydroxide are employed. The overall yield is around 75-85%, with high purity achieved through recrystallization and chromatographic methods.

What industries use Cefazolin Impurity C (CAS: 56842-77-4)?

Cefazolin Impurity C is primarily used in the pharmaceutical industry for quality control and impurity profiling of cephalosporin antibiotics. It is also relevant in analytical chemistry for developing standards and reference materials.

What precautions should be taken when handling Cefazolin Impurity C (CAS: 56842-77-4)?

When handling Cefazolin Impurity C, use appropriate personal protective equipment (PPE) including gloves, goggles, and a lab coat. Store it in a well-ventilated area and avoid inhaling dust or fumes. In case of spill, neutralize with a suitable reagent and dispose of according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed information.