(4-Fluorophenyl)(4-piperidinyl)methanone

Basic Information

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CAS Number

56346-57-7

Molecular Formula

C12H14FNO

Molecular Weight

207.25 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ketones

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Physical State

OFF-WHITE SOLID

Boiling Point

323.2±32.0 °C at 760 mmHg

Density

1.1±0.1 g/cm3

Flash Point

149.3±25.1 °C

Vapor Pressure

0.0±0.7 mmHg at 25°C

SMILES

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C1CNCCC1C(=O)C2=CC=C(C=C2)F

InChI

InChI=1S/C12H14FNO/c13-11-3-1-9(2-4-11)12(15)10-5-7-14-8-6-10/h1-4,10,14H,5-8H2

InChIKey

ABERUOJGWHYBJL-UHFFFAOYSA-N

LogP

2.008

Topological Polar Surface Area

29.1 Å²

Hydrogen Bond Donor/Acceptor

1 / 2

Complexity

218

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

(4-Fluoro-phenyl)-piperidin-4-yl-methanone
DTXSID001347223
AB14167
(4-fluorophenyl)(4-piperidinyl)methanone
CHEMBL148189
4-(4-fluorobenzoyl) piperidine
ABERUOJGWHYBJL-UHFFFAOYSA-N
4-(p-fluorobenzoyl)-piperidine
Oprea1_026899
AKOS000200078
(4-fluorophenyl) (4-piperidinyl) methanone
(4-Fluoro-phenyl)-piperidin4-yl-methanone
AC-6306
FT-0616622
Maybridge1_003304
(4-fluorophenyl) (4-piperidinyl)methanone
BRD-K68125677-003-01-5
4-(P-FLUOROBENZOYL)PIPERIDINE
FS-4439
(4-fluorophenyl)piperidin-4-ylmethanone
(4-fluorophenyl)-piperidin-4-ylmethanone
4K4JJ6US7T
4-(4-fluorbenzoyl)piperidine
4-(4-fluorobenzoyl)piperidine, AldrichCPR
4-(4-fluoro-benzoyl)-piperidine
AM20040728
4-Fluorophenyl piperidin-4-yl methanone
4-(4'-fluorobenzoyl)piperidine
4-(4-Fluorobenzoyl)piperidine
CCG-243729
EN300-26355

MDL Number

MFCD03411595

Customs Code

2933399090

FAQ

What are the physical and chemical properties of (4-Fluorophenyl)(4-piperidinyl)methanone (CAS: 56346-57-7)?

(4-Fluorophenyl)(4-piperidinyl)methanone is a white crystalline solid with a molecular weight of approximately 242.22 g/mol. It has a low solubility in water but is soluble in organic solvents like ethanol and dichloromethane. The compound is relatively stable but can react with strong bases. It does not have significant reactivity under normal conditions but should be handled with care due to its functional groups.

How is (4-Fluorophenyl)(4-piperidinyl)methanone (CAS: 56346-57-7) typically synthesized?

(4-Fluorophenyl)(4-piperidinyl)methanone is synthesized via a multi-step process, often involving the reaction of 4-fluoroaniline with piperidine in the presence of a suitable base such as sodium hydroxide. The yield is typically around 80-90%, and the selectivity for the desired product is high. The final step involves methylation using methyl iodide and a base like potassium carbonate.

What industries use (4-Fluorophenyl)(4-piperidinyl)methanone (CAS: 56346-57-7)?

(4-Fluorophenyl)(4-piperidinyl)methanone is used in the pharmaceutical industry as a precursor for the synthesis of various drugs. It is also utilized in the polymer industry for the development of new materials. Additionally, it has potential applications in the production of sensors and semiconductors due to its unique chemical properties.

What precautions should be taken when handling (4-Fluorophenyl)(4-piperidinyl)methanone (CAS: 56346-57-7)?

When handling (4-Fluorophenyl)(4-piperidinyl)methanone, it is essential to wear appropriate personal protective equipment (PPE) such as gloves, safety glasses, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to minimize exposure. Spills should be cleaned up immediately using appropriate methods and materials. Always refer to the Safety Data Sheet (SDS) for detailed safety instructions and emergency procedures.