(R)-Viloxazine Hydrochloride

Basic Information

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CAS Number

56287-63-9

Molecular Formula

C13H20ClNO3

Molecular Weight

273.76 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Melting Point

158-161°C

SMILES

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CCOC1=CC=CC=C1OCC2CNCCO2.Cl

InChI

InChI=1S/C13H19NO3.ClH/c1-2-15-12-5-3-4-6-13(12)17-10-11-9-14-7-8-16-11;/h3-6,11,14H,2,7-10H2,1H3;1H/t11-;/m1./s1

InChIKey

HJOCKFVCMLCPTP-RFVHGSKJSA-N

LogP

1.8742999999999994

Topological Polar Surface Area

39.72 Å²

Hydrogen Bond Donor/Acceptor

1 / 4

Complexity

213

Synonyms & References

English

(R)-Viloxazine Hydrochloride
(2R)-2-[(2-ethoxyphenoxy)methyl]morpholine,hydrochloride
(R)-Viloxazine Hydro
E74822
BS-46161
(2R)-2-[(2-ethoxyphenoxy)methyl]morpholine;hydrochloride
(2R)-2-(2-ETHOXYPHENOXYMETHYL)MORPHOLINE HYDROCHLORIDE
CS-0142017
AKOS040745076
(R)-Viloxazine (hydrochloride)
56287-63-9
(R)-2-((2-Ethoxyphenoxy)methyl)morpholine hydrochloride
HY-125784A
(2R)-2-[(2-ethoxyphenoxy)methyl]morpholine hydrochloride

MDL Number

MFCD18379655

FAQ

What are the physical and chemical properties of (R)-Viloxazine Hydrochloride (CAS: 56287-63-9)?

(R)-Viloxazine Hydrochloride is a crystalline compound with a molecular weight of approximately 291.7 g/mol. It has a solubility of about 29 mg/mL in water. It is relatively stable under normal conditions but can react with bases to form the free base. The compound is commonly used in pharmaceutical applications and has a bitter taste.

How is (R)-Viloxazine Hydrochloride (CAS: 56287-63-9) typically synthesized?

(R)-Viloxazine Hydrochloride is typically synthesized through a series of steps including the condensation of a suitable aromatic amine with a chloroacetyl chloride, followed by hydrogenation to introduce the (R)-configuration. The reaction is catalyzed by palladium and uses a ligand to control the enantiomeric selectivity, achieving a yield of around 80%.

What industries use (R)-Viloxazine Hydrochloride (CAS: 56287-63-9)?

(R)-Viloxazine Hydrochloride is primarily used in the pharmaceutical industry. It is an intermediate used in the synthesis of certain antidepressant drugs. In addition, it may have applications in the polymer and sensor industries due to its chemical properties.

What precautions should be taken when handling (R)-Viloxazine Hydrochloride (CAS: 56287-63-9)?

When handling (R)-Viloxazine Hydrochloride, it is important to wear appropriate personal protective equipment (PPE), including gloves and safety glasses. The compound should be stored in a cool, dry place away from direct sunlight. In case of a spill, it should be cleaned up using appropriate methods and equipment, and a safety data sheet (SDS) should be consulted for detailed procedures.