2-[(5-Nitro-1,3-thiazol-2-yl)carbamoyl]phenyl acetate

Basic Information

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CAS Number

55981-09-4

Molecular Formula

C12H9N3O5S

Molecular Weight

307.28 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Esters

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Basic Physical Properties

Melting Point

198.0 to 202.0 deg-C

Boiling Point

[394]

Density

1.532

SMILES

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CC(=O)Oc1ccccc1C(=O)Nc2ncc(s2)[N+](=O)[O-]

InChI

InChI=1S/C12H9N3O5S/c1-7(16)20-9-5-3-2-4-8(9)11(17)14-12-13-6-10(21-12)15(18)19/h2-6H,1H3,(H,13,14,17)

InChIKey

YQNQNVDNTFHQSW-UHFFFAOYSA-N

LogP

2.82510

Complexity

428

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

Toxicity

LD50 orally in male, female mice: 1350, 1380 mg/kg; in rats: >10 g/kg (Murphy, Friedmann)

Synonyms & References

English

Nitazoxanide
2-(acetolyloxy)-n-(5-nitro-2-thiazolyl)benzamide
2-(acetyloxy)-n-(5-nitro-2-thiazolyl)-benzamid
n-(5-nitro-2-thiazolyl)-salicylamidacetate(ester)
n-(5-nitro-2-thiazolyl)salicylamideacetate(ester)
AURORA KA-645
o-[n-(5-nitrothiazol-2-yl)carbamoyl]phenyl acetate
nitazoxamide
[2-[(5-nitro-1,3-thiazol-2-yl)carbamoyl]phenyl] acetate
2-((5-Nitrothiazol-2-yl)carbamoyl)phenyl acetate
Nitazoxanide (NTZ,NSC 697855)
[14C]-Nitazoxanide
Alinia
Colufase
Cryptaz
Daxon
Heliton
Nitazoxanida
Nitazoxanidum
NSC 697855
NTZ
2-(Acetyloxy)-N-(5-nitro-2-thiazolyl)benzamide
Nitazoxanidum [INN-Latin]
Nitazoxanida [INN-Spanish]
Nitazoxanid
Phavic-1
2-[(5-nitro-1,3-thiazol-2-yl)carbamoyl]phenyl acetate
Benzamide, 2-(acetyloxy)-N-(5-nitro-2-thiazolyl)-
C12H9N3O5S
NSC697855
2-Acetyloxy-N-[(5-nitro-2-thiazolyl)]benzamide

MDL Number

MFCD00416599

Customs Code

2942000000

FAQ

What is 2-[(5-Nitro-1,3-thiazol-2-yl)carbamoyl]phenyl acetate (CAS: 55981-09-4)?

2-[(5-Nitro-1,3-thiazol-2-yl)carbamoyl]phenyl acetate is a chemical compound with the CAS number 55981-09-4. It belongs to the class of thiazole derivatives and contains a carbamoyl group attached to a phenyl ring. This compound is characterized by its aromatic structure and functional groups, making it useful in various chemical applications. It is often used as an intermediate in the synthesis of pharmaceuticals and other organic compounds.

What are the main uses of 2-[(5-Nitro-1,3-thiazol-2-yl)carbamoyl]phenyl acetate (CAS: 55981-09-4)?

2-[(5-Nitro-1,3-thiazol-2-yl)carbamoyl]phenyl acetate (CAS: 55981-09-4) is primarily used in pharmaceutical research as a building block for the development of drugs. It may also find applications in agrochemicals and organic synthesis due to its reactivity and structural versatility. Its use in industrial processes and as a research compound is supported by its chemical properties and functional group composition.

Is 2-[(5-Nitro-1,3-thiazol-2-yl)carbamoyl]phenyl acetate (CAS: 55981-09-4) safe?

Safety of 2-[(5-Nitro-1,3-thiazol-2-yl)carbamoyl]phenyl acetate (CAS: 55981-09-4) depends on its handling and exposure conditions. As a chemical intermediate, it may have potential toxicity and should be handled with appropriate protective measures. It is recommended to follow safety guidelines, use personal protective equipment, and ensure proper ventilation when working with this compound to minimize health risks.

How should 2-[(5-Nitro-1,3-thiazol-2-yl)carbamoyl]phenyl acetate (CAS: 55981-09-4) be stored?

2-[(5-Nitro-1,3-thiazol-2-yl)carbamoyl]phenyl acetate (CAS: 55981-09-4) should be stored in a cool, dry, and well-ventilated area, away from direct light. It is typically kept in airtight containers to prevent moisture ingress and maintain chemical stability. Proper storage conditions are essential to preserve its properties and ensure safe handling during use.