Sunitinib | CAS No. 557795-19-4

Sunitinib

Basic Information

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CAS Number

557795-19-4

Molecular Formula

C22H27FN4O2

Molecular Weight

398.48 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Physical State

Orange solid

Melting Point

229-242°C

Boiling Point

572.1°C at 760 mmHg

Density

1.2

Flash Point

299.8℃

Solubility

>25 mg/mL over pH of 1.2 to 6.8

Vapor Pressure

1.26X10-14 mm Hg at 25 °C (est)

SMILES

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CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C/2\C(=O)Nc3ccc(F)cc23)c1C

InChI

InChI=1S/C22H27FN4O2/c1-5-27(6-2)10-9-24-22(29)20-13(3)19(25-14(20)4)12-17-16-11-15(23)7-8-18(16)26-21(17)28/h7-8,11-12,25H,5-6,9-10H2,1-4H3,(H,24,29)(H,26,28)/b17-12-

InChIKey

WINHZLLDWRZWRT-ATVHPVEESA-N

LogP

3.3349400000000013

pKa

8.5(at 25℃)

Topological Polar Surface Area

77.23 Å²

Hydrogen Bond Donor/Acceptor

3 / 6

Complexity

636

Safety Information

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Hazard Statement

H360 May damage fertility or the unborn child
Reproductive toxicity

H372 Causes damage to organs through prolonged or repeated exposure
Specific target organ toxicity, repeated exposure

Synonyms & References

English

1H-Pyrrole-3-carboxamide, N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-
N-(2-(Diethylamino)ethyl)-5-((Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide
N-(2-diethylaminoethyl)-5-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide
1H-Pyrrole-3-carboxamide, N-(2-(diethylamino)ethyl)-5-((Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl)-2,4-dimethyl-
(Z)-N-(2-(diethylamino)ethyl)-5-((5-fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide
Sunitinib
2-Methyl-sulphanyl-4,6-dihydrothiazoline hydroiodide
&nbsp
5-(5-Fluoro-2-oxo-1,2-Dihydroindol-3-Ylidenemethyl)-2,4-Dimethyl-1H-Pyrrole-3-Carboxylic Acid (2-Diethylamino-Ethyl)Amide
N-[2-(diethylamino)ethyl]-5-[(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide
SU 11248
SU-11248
Suniti
SUNITINIB BASE
SUNITINIB MALEATE
SUNITINIB-D4
Sutent-d4
Sutent
Sunitinib malate
SU11248
sunitinibum
N-[2-(diethylamino)ethyl]-5-{[(3Z)-5-fluoro-2-oxo-2,3-dihydro-1H-indol-3-ylidene]methyl}-2,4-dimethyl-1H-pyrrole-3-carboxamide
N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide
NSC750690
V99T50803M
(Z)-N-(2-(Diethylamino)ethyl)-5-((5-fluoro-2-oxoindolin-3-ylidene)m
SU011

MDL Number

MFCD09260778

FAQ

What is Sunitinib (CAS: 557795-19-4)?

Sunitinib is a multi-targeted tyrosine kinase inhibitor used in pharmaceutical applications. Its chemical formula is C19H22N4O4S, and it exhibits good solubility in DMSO and ethanol. It is known for its ability to inhibit various receptor tyrosine kinases, making it a valuable compound in drug development and research.

What are the main uses of Sunitinib (CAS: 557795-19-4)?

Sunitinib is primarily used in the treatment of certain cancers, including gastrointestinal stromal tumors (GIST) and renal cell carcinoma. As a pharmaceutical compound, it also serves as a research tool for studying kinase pathways and developing new therapeutic agents. Its versatility in targeting multiple kinases makes it a key component in drug discovery and biomedical research.

Is Sunitinib (CAS: 557795-19-4) safe?

Sunitinib is generally considered safe when used under medical supervision, but it may cause side effects such as fatigue, diarrhea, and hypertension. Proper handling and adherence to safety guidelines are essential during storage and use. It is important to follow standard safety protocols to minimize exposure risks and ensure safe usage in both laboratory and clinical settings.

How should Sunitinib (CAS: 557795-19-4) be stored?

Sunitinib should be stored in a cool, dry place away from light. It is typically kept in a sealed container at a temperature between 2°C and 8°C. Maintaining proper humidity levels and avoiding exposure to moisture is crucial for preserving its stability and potency. Always store it in a well-ventilated area and follow recommended safety precautions.