4-Aminobenzaldehyde

Basic Information

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CAS Number

556-18-3

Molecular Formula

C7H7NO

Molecular Weight

121.14 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Aldehydes

Basic Chemical Raw Materials Organic Chemicals Amines

Fine Chemicals Dyes and Pigments Organic Dyes

Basic Physical Properties

Melting Point

71-72 °C

Boiling Point

138-139 C

Refractive Index

1.5323 (estimate)

SMILES

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C1=CC(=CC=C1C=O)N

InChI

InChI=1S/C7H7NO/c8-7-3-1-6(5-9)2-4-7/h1-5H,8H2

InChIKey

VATYWCRQDJIRAI-UHFFFAOYSA-N

LogP

1.0813000000000001

Topological Polar Surface Area

43.09 Å²

Hydrogen Bond Donor/Acceptor

2 / 2

Complexity

95.1

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

SY003470
p-amino-benzaldehyde
556-18-3
4-Aminobenzaldehyde
p-Aminobenzaldehyd
BRN 1362885
DTXSID3060299
Benzaldehyde, 4-amino-
4-Aminobenzaldehyde, AldrichCPR
CHEBI:190128
NSC-60117
NS00033354
NSC60117
74Q1671TS1
CHEMBL1885510
EN300-85865
J-514422
GS-3084
MFCD00038137
HY-W076836
p-Formylaniline
A830723
CCRIS-8885
CCRIS 8885
WLN: ZR DVH
UNII-74Q1671TS1
4-Formylaniline
A0260
Q21099246
4-azanylbenzaldehyde
SCHEMBL214899

MDL Number

MFCD00038137

FAQ

What are the physical and chemical properties of 4-Aminobenzaldehyde (CAS: 556-18-3)?

4-Aminobenzaldehyde (CAS: 556-18-3) is a white crystalline solid with a molecular weight of 123.12 g/mol. It is slightly soluble in water and more soluble in organic solvents like ethanol and acetone. It is an electrophilic aromatic compound and reacts readily with nucleophiles. It has a vapor pressure of less than 0.1 mmHg at 25°C, indicating low volatility. Its solubility makes it useful in various organic synthesis reactions.

How is 4-Aminobenzaldehyde (CAS: 556-18-3) typically synthesized?

4-Aminobenzaldehyde (CAS: 556-18-3) can be synthesized using the reduction of 4-formylbenzeneamine with a suitable reducing agent like sodium borohydride. Another method involves the condensation of salicylaldehyde and hydroxylamine. The yield is typically around 70-80%, and the reaction is performed in aqueous solutions, with careful control of pH and temperature to achieve high selectivity and yield.

What industries use 4-Aminobenzaldehyde (CAS: 556-18-3)?

4-Aminobenzaldehyde (CAS: 556-18-3) is widely used in the pharmaceutical industry for the synthesis of various drugs. It is also utilized in the production of dyes, pigments, and in the manufacturing of polymers and resins. Additionally, it is used as a starting material in semiconductor and sensor applications due to its unique reactivity and functional groups.

What precautions should be taken when handling 4-Aminobenzaldehyde (CAS: 556-18-3)?

When handling 4-Aminobenzaldehyde (CAS: 556-18-3), it is crucial to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to prevent inhalation of vapors. Spills should be cleaned up using appropriate absorbents and discarded according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed handling and storage instructions.