3-Furylboronic acid

Basic Information

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CAS Number

55552-70-0

Molecular Formula

C4H5BO3

Molecular Weight

111.89 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

Physical State

White to Yellow Solid

Melting Point

139-144 °C (dec.)

Boiling Point

247.7°C at 760 mmHg

Density

1.25

Flash Point

103.6 °C

Solubility

Soluble in methanol.

Refractive Index

1.49

SMILES

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B(C1=COC=C1)(O)O

InChI

InChI=1S/C4H5BO3/c6-5(7)4-1-2-8-3-4/h1-3,6-7H

InChIKey

CYEFKCRAAGLNHW-UHFFFAOYSA-N

LogP

-1.0406000000000002

Topological Polar Surface Area

53.6 Å²

Hydrogen Bond Donor/Acceptor

2 / 3

Complexity

75.7

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

Hazard Class

Class IRRITANT Class IRRITANT

Class AIR SENSITIVE Class AIR SENSITIVE

Class KEEP COLD Class KEEP COLD

Sensitiveness

sensitive to heat

Synonyms & References

English

3-Furanboronic acid
3-furyl boronic acid
GS-6852
FT-0601790
3-furan boronic acid
3-Furanylboronic acid, >=95.0%
F0438
55552-70-0
Furan-3-boronic acid
3-furylboronic Acid
AKOS009158919
MFCD01319007
J-521400
furan -3-boronic acid
CS-W001222
furan-3-ylboronic acid
SY001064
3-Furanboronicacid
Z1179935144
DTXSID30370248
(furan-3-yl)boronic acid
3-furanyl boronic acid
EN300-87221
CYEFKCRAAGLNHW-UHFFFAOYSA-N
Furan-3-boronicacid;FURAN-3-BORONIC ACID
3-furane boronic acid
A8031
NCGC00249550-01
3-furaneboronic acid
SCHEMBL42461
F0001-1458

MDL Number

MFCD01319007

Customs Code

2932190090

FAQ

What are the physical and chemical properties of 3-Furylboronic acid (CAS: 55552-70-0)?

3-Furylboronic acid is a white or off-white crystalline solid with a molecular weight of approximately 156.09 g/mol. It has a low solubility in water but is more soluble in organic solvents such as methanol and ethanol. It exhibits good reactivity towards various functional groups in organic synthesis, particularly in coupling reactions with aryl halides and triflates.

How is 3-Furylboronic acid (CAS: 55552-70-0) typically synthesized?

3-Furylboronic acid is commonly synthesized via the Birch reduction of 3-furylacetonitrile followed by boronation using pinacol borane. The reaction is conducted in an anhydrous, inert atmosphere. This method provides good yield and is selective for the target product.

What industries use 3-Furylboronic acid (CAS: 55552-70-0)?

3-Furylboronic acid is used in the pharmaceutical industry for the synthesis of drug molecules, in the polymer industry for the synthesis of functional polymers, and in the semiconductor industry for the preparation of boron-doped materials. It also finds applications in the development of sensors and other advanced materials.

What precautions should be taken when handling 3-Furylboronic acid (CAS: 55552-70-0)?

When handling 3-Furylboronic acid, it is important to use personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work in a well-ventilated area or a fume hood to avoid inhalation of dust. Spills should be cleaned up using appropriate chemicals and disposal methods. Always refer to the Safety Data Sheet (SDS) for detailed handling and storage instructions.