3-Furylboronic acid(CAS: 55552-70-0)

3-Furylboronic acid is a white or off-white crystalline solid with a molecular weight of approximately 156.09 g/mol. It has a low solubility in water but is more soluble in organic solvents such as methanol and ethanol. It exhibits good reactivity towards various functional groups in organic synthesis, particularly in coupling reactions with aryl halides and triflates.

3-Furylboronic acid is commonly synthesized via the Birch reduction of 3-furylacetonitrile followed by boronation using pinacol borane. The reaction is conducted in an anhydrous, inert atmosphere. This method provides good yield and is selective for the target product.

3-Furylboronic acid is used in the pharmaceutical industry for the synthesis of drug molecules, in the polymer industry for the synthesis of functional polymers, and in the semiconductor industry for the preparation of boron-doped materials. It also finds applications in the development of sensors and other advanced materials.

When handling 3-Furylboronic acid, it is important to use personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work in a well-ventilated area or a fume hood to avoid inhalation of dust. Spills should be cleaned up using appropriate chemicals and disposal methods. Always refer to the Safety Data Sheet (SDS) for detailed handling and storage instructions.