Dexamethasone sodium phosphate

Basic Information

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CAS Number

55203-24-2

Molecular Formula

C22H28FNa2O8P

Molecular Weight

516.4 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ketones

Fine Chemicals Surfactants Anionic Surfactants

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Insecticides

Polymers and Plastics Thermoplastics Polyolefins

Basic Physical Properties

Melting Point

233-235℃

Boiling Point

568.2°C at 760 mmHg

Density

1.32

Flash Point

297.5°C

Solubility

H2O: 50 mg/mL, clear, faintly yellow

Refractive Index

1.591

SMILES

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CC1CC2C3CCC4=CC(=O)C=CC4(C3(C(CC2(C1(C(=O)COP(=O)([O-])[O-])O)C)O)F)C.[Na+].[Na+]

InChI

InChI=1S/C22H30FO8P.2Na/c1-12-8-16-15-5-4-13-9-14(24)6-7-19(13,2)21(15,23)17(25)10-20(16,3)22(12,27)18(26)11-31-32(28,29)30;;/h6-7,9,12,15-17,25,27H,4-5,8,10-11H2,1-3H3,(H2,28,29,30);;/q;2*+1/p-2/t12-,15+,16+,17+,19+,20+,21+,22+;;/m1../s1

InChIKey

PLCQGRYPOISRTQ-FCJDYXGNSA-L

LogP

2.88910

Complexity

962

Synonyms & References

English

Dexamethasone sodium phosphate, European Pharmacopoeia (EP) Reference Standard
PLCQGRYPOISRTQ-FCJDYXGNSA-L
NS00083368
DEXAMETHASONE SODIUM PHOSPHATE [JAN]
NCGC00256783-01
Maxidex Ointment
A816989
Cebedex
Dexamethasone phosphate disodium
Dexair
2392-39-4
Dexium-SP
D00975
Dexamethasone disodium phosphate
Ak-Dex
CHEMBL2021430
Viadox
Spersadox
Dexagel
MAS CARE-PAK DEXAMETHASONE
Q27106391
DEXAMETHASONE 21-PHOSPHATE DISODIUM SALT [MI]
A830522
Colvasone
Dexaject SP
AC-17992
AI9376Y64P
Dexamethasone sodium phosphate for peak identification, European Pharmacopoeia (EP) Reference Standard
Disodium dexamethasone phosphate
disodium 9-fluoro-11beta,17-dihydroxy-16alpha-methyl-3,20-dioxopregna-1,4-dien-21-yl phosphate
DEXAMETHASONE SODIUM PHOSPHATE (USP IMPURITY)

MDL Number

MFCD28386101

Customs Code

2937290090

FAQ

What are the physical and chemical properties of Dexamethasone sodium phosphate (CAS: 55203-24-2)?

Dexamethasone sodium phosphate is a white, crystalline powder with a molecular weight of approximately 532.63 g/mol. It is slightly soluble in water and has low solubility in ethanol. It is stable under normal conditions but can undergo hydrolysis in the presence of strong acids or bases. The compound is not flammable and has a low reactivity under normal laboratory conditions.

How is Dexamethasone sodium phosphate (CAS: 55203-24-2) typically synthesized?

Dexamethasone sodium phosphate is synthesized by first preparing dexamethasone acetate, which is then converted to the sodium phosphate salt. The synthesis involves several steps, including acetylation, reduction, and phosphonation. Common catalysts include sodium hydroxide and phosphoric acid. The overall process yields a product with high purity and selectivity, suitable for pharmaceutical applications.

What industries use Dexamethasone sodium phosphate (CAS: 55203-24-2)?

Dexamethasone sodium phosphate is primarily used in the pharmaceutical industry for the treatment of various inflammatory and immune disorders. It is also used in veterinary medicine. Additionally, it can be used in some sensor and semiconductor applications for its steroidal structure.

What precautions should be taken when handling Dexamethasone sodium phosphate (CAS: 55203-24-2)?

When handling Dexamethasone sodium phosphate, it is essential to wear appropriate personal protective equipment (PPE), including gloves, lab coat, and safety goggles. Store the compound in a cool, dry place away from direct sunlight and heat sources. In case of a spill, use appropriate cleanup methods and consult the Material Safety Data Sheet (MSDS) or Safety Data Sheet (SDS) for detailed instructions. Fume hoods should be used during preparation to minimize inhalation risks.