Betahistine mesylate

Basic Information

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CAS Number

54856-23-4

Molecular Formula

C10H20N2O6S2

Molecular Weight

232.31 g/mol

Basic Physical Properties

Melting Point

112.0 to 115.0 deg-C

Water Solubility

almost transparency

SMILES

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CNCCC1=CC=CC=N1.CS(=O)(=O)O.CS(=O)(=O)O

InChI

InChI=1S/C8H12N2.CH4O3S/c1-9-7-5-8-4-2-3-6-10-8;1-5(2,3)4/h2-4,6,9H,5,7H2,1H3;1H3,(H,2,3,4)

InChIKey

FUWLKZQYMWTFBA-UHFFFAOYSA-N

LogP

0.3474999999999999

Topological Polar Surface Area

79.29 Å²

Hydrogen Bond Donor/Acceptor

2 / 5

Complexity

176

Safety Information

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GHS Hazard Pictograms

H303

Hazard Statement

H303 May be harmful if swallowed
Acute toxicity, oral

Synonyms & References

English

CS-0010146
Bethahistinemethanesulfonate;Betahistine Mesilate
Merislon
N-Methyl-2-(pyridin-2-yl)ethan-1-amine dimethanesulfonate
D87714
HY-D0237
W-105601
SR-01000722006-3
SCHEMBL194604
methanesulfonic acid;N-methyl-2-pyridin-2-ylethanamine
MFCD00211321
CCG-220543
Q27293318
2-PYRIDINEETHANAMINE, N-METHYL-, METHANESULFONATE (1:2)
Riptonin
betahistine dimethanesulfonate
HMS3713N07
Betahistine (mesylate)
EINECS 259-377-7
BETAHISTINE MESILATE [MART.]
FT-0622912
AC-23916
2-PYRIDINEETHANAMINE, N-METHYL-, METHANESULPHONATE (1:2)
HMS2096N07
UNII-X1L0E3R43Y
CHEBI:31274
BETAHISTINE MESILATE [EP IMPURITY]
N-Methyl-2-(2-pyridinyl)ethanamine methanesulfonate
Meginalisk
Betahistine mesylate
N-methyl-2-(pyridin-2-yl)ethanamine dimethanesulfonate

MDL Number

MFCD00211321

Customs Code

2933399090

FAQ

What are the physical and chemical properties of Betahistine mesylate (CAS: 54856-23-4)?

Betahistine mesylate is a white or practically white crystalline powder. It has a molecular weight of approximately 418.5 g/mol and a high solubility in water. It is relatively stable under normal conditions but can undergo hydrolysis in the presence of water and acid. It is used in the treatment of vertigo and other symptoms of inner ear disorders.

How is Betahistine mesylate (CAS: 54856-23-4) typically synthesized?

Betahistine mesylate is synthesized through an acylation reaction of betahistine with methanesulfonyl chloride. The reaction is typically performed in the presence of a base such as triethylamine. The product is then purified by recrystallization. This method provides good selectivity and yields up to 95%.

What industries use Betahistine mesylate (CAS: 54856-23-4)?

Betahistine mesylate (CAS: 54856-23-4) is primarily used in the pharmaceutical industry for the treatment of vertigo and other inner ear disorders. It is also used in the cosmetics industry for its vasodilatory properties.

What precautions should be taken when handling Betahistine mesylate (CAS: 54856-23-4)?

When handling Betahistine mesylate (CAS: 54856-23-4), it is important to use personal protective equipment such as gloves and goggles to protect against skin and eye contact. Handling should be carried out in a fume hood to avoid inhalation. Spills should be cleaned up using appropriate absorbent materials and the area should be ventilated. Always refer to the Material Safety Data Sheet (MSDS) for detailed safety information.